Multi-Omics of Single Cells: Strategies and Applications.

Multi-Omics of Single Cells: Strategies and Applications.
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DOI:
10.1016/j.tibtech.2016.04.004
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发表时间:
2016-08
影响因子:
17.3
通讯作者:
Sheffield NC
Sheffield NC
中科院分区:
工程技术1区
文献类型:
--
作者:
Bock C;Farlik M;Sheffield NC

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大多数全基因组分析提供了大量细胞的平均值,但最近的技术进步有望克服这一限制。开创性的单细胞分析现在可用于基因组、表观基因组、转录组、蛋白质组和代谢组分析。在这里,我们描述了如何将这些不同的维度结合到多组学分析中,以提供相同细胞的全面概况。
Most genome-wide assays provide averages across large numbers of cells, but recent technological advances promise to overcome this limitation. Pioneering single-cell assays are now available for genome, epigenome, transcriptome, proteome, and metabolome profiling. Here, we describe how these different dimensions can be combined into multi-omics assays that provide comprehensive profiles of the same cell.