Distribution of parvalbumin immunoreactivity in the neocortex of hypothyroid adult rats
Distribution of parvalbumin immunoreactivity in the neocortex of hypothyroid adult rats
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DOI：
10.1016/0304-3940(96)12318-1
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发表时间：
1996-02-02
影响因子：
2.5
通讯作者：
DeFelipe, J
中科院分区：
文献类型：
--
作者：
Berbel, P;Marco, P;DeFelipe, J
早期甲状腺功能减退会对大脑造成全身性损害，特别是新皮质感觉区连通性的改变。本文用小白蛋白(PV)免疫细胞化学方法研究了正常和甲状腺功能减退成年大鼠局部新皮质环路的潜在变化。两组PV阳性细胞的数目和径向分布相似，但在甲状腺功能减退大鼠，PV阳性终末点状突起的密度明显减少，尤其是在第II-III层和IV-V、VI层下部。这些结果表明，甲状腺激素是参与PV阳性细胞的皮质环路正常发育所必需的。
Early hypothyroidism produces a generalized damage in the brain and in particular, changes in the connectivity of neocortical sensory areas. In this paper, the potential alterations in local neocortical circuits have been explored using immunocytochemistry for parvalbumin (PV) in normal and hypothyroid adult rats. The number and radial distribution of PV-positive cells were similar in both groups, but in hypothyroid rats, the density of PV-positive terminal-like puncta and processes was dramatically reduced, especially in layers II-III and the lower part of layers IV-V and VI. These results suggest that thyroid hormones are necessary for normal development of cortical circuits in which PV-positive cells are involved.