Five-year follow-up of a cohort of profoundly immunosuppressed patients discontinuing therapy for cytomegalovirus retinitis.
Five-year follow-up of a cohort of profoundly immunosuppressed patients discontinuing therapy for cytomegalovirus retinitis.
复制标题
对一组因巨细胞病毒视网膜炎而停止治疗的严重免疫抑制患者进行的五年随访。
DOI：
10.1097/00002030-200402200-00027
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Polis,MichaelA
中科院分区：
文献类型：
--
作者：
Sklar,PeterA;Agyemang,AmmaF;Monastra,Rachelle;Kress,DianeRock;Metcalf,JuliaA;Robinson,MichaelR;Masur,Henry;Polis,MichaelA
Potent antiretroviral therapy stimulates robust and durable immune reconstitution among profoundly immunosuppressed patients that is clinically important. Fifteen patients with cytomegalovirus retinitis (CMVR) were followed after discontinuing anti-cytomegalovirus therapy. No patient had progression or relapse for a median of 51 months. Survival from the diagnosis of CMVR was universal for up to 95 months, with an observation period averaging more than 6 years. The CD4 cell count continued to rise through the fourth year of follow-up.Before the widespread use of highly active antiretroviral therapy (HAART) in developed countries, cytomegalovirus retinitis (CMVR) was a significant cause of morbidity and a predictor of mortality. Recent studies have demonstrated that chronic maintenance therapy may be safely discontinued among patients with CMVR whose CD4 lymphocyte counts have demonstrated a sustained increase to more than 50–150 cells/mm 3 in response to HAART [1–6].
