Prognostic factors in buprenorphine- versus methadone-maintained patients
Prognostic factors in buprenorphine- versus methadone-maintained patients
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DOI：
10.1097/00005053-199801000-00006
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发表时间：
1998-01-01
影响因子：
1.9
通讯作者：
Kosten, TR
中科院分区：
文献类型：
--
作者：
Schottenfeld, RS;Pakes, JR;Kosten, TR
本研究a)比较丁丙诺啡和美沙酮维持治疗对苯二氮类药物和酒精使用的影响，b)评估性别和精神病理学的预后意义及其与维持治疗的相互作用。男80例，女36例，随机分为丁丙诺啡(4 mg或12 mg)和美沙酮(20 mg或65 mg)两组。维持性药物与酒精或苯二氮类药物使用的显著差异无关。女性对非法阿片类药物的戒断率明显较高；在丁丙诺啡4毫克组中，女性的保留率也明显较好，阿片类药物阳性尿样的比率较低，非法阿片类药物的戒断率较高。终生镇静依赖与显著改善的保留率、可卡因阳性尿样的降低和可卡因戒断率的增加有关；在丁丙诺啡而不是美沙酮维持的患者中，这也与非法阿片类药物戒断率的增加有关。
This study a) compared the effects of buprenorphine versus methadone maintenance on benzodiazepine and alcohol use and b) evaluated the prognostic significance of gender and psychopathology and their interaction with maintenance treatment. Eighty male and 36 female patients were randomly assigned to daily sublingual buprenorphine (4 or 12 mg) or oral methadone (20 or 65 mg). Maintenance medication was not associated with significant differences in alcohol or benzodiazepine use. Rates of abstinence from illicit opioids were significantly higher for females; within the buprenorphine 4-mg group, females also had significantly better retention, lower rates of opioid-positive urine samples, and higher rates of abstinence from illicit opioids. Lifetime sedative dependence was associated with significantly better retention, decreased rates of cocaine-positive urine samples, and increased rates of cocaine abstinence; among buprenorphine-but not methadone-maintained patients, it was also associated with increased rates of abstinence from illicit opioids.