Therapeutics strategies against cancer stem cell in breast cancer
Therapeutics strategies against cancer stem cell in breast cancer
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DOI：
10.1016/j.biocel.2019.01.015
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发表时间：
2019-04-01
影响因子：
4
通讯作者：
Esmaeilzadeh, Abdolreza
中科院分区：
文献类型：
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作者：
Ghasemi, Faezeh;Sarabi, Parisa Zia;Esmaeilzadeh, Abdolreza
乳腺癌被认为是世界范围内妇女中最常见的癌症和第二致命的癌症。由于乳腺癌的高发病率和常规治疗的局限性，在癌细胞中寻找新的靶点并直接靶向它们似乎是必要的，例如针对乳腺癌干细胞的靶向治疗。在这篇综述中，我们指出了一些癌症干细胞在乳腺癌中的治疗用途。一些策略是靶向其微环境中的表面特异性标志物和活化的信号通路，例如Notch、Hedgehog、Wnt/b-连环蛋白、PI 3 K/Akt、NF-kB、BMP和TGF-β及其维持和耐药性，使用各种miRNA，增强CSC凋亡，分化治疗，阻断上皮向间充质转化和使用不同的天然化合物。近年来的研究表明，肿瘤干细胞在乳腺癌的靶向治疗中发挥着重要作用。癌症干细胞的新操作方法可用作乳腺癌的靶向治疗，这在癌症免疫治疗中得到了强调。
Breast cancer is known as a most prevalent cancer and second deadly cancer, among women worldwide. Due to the high incidence rate of breast cancer and limitations of conventional therapy it seemed essential to look for new targets in cancer cells and directly target them such as target therapy on breast cancer stem cells. In this review we indicate some of therapeutic uses of cancer stem cells in breast cancer. Some strategies are targeting surface specific markers and activated signaling pathways in their microenvironment such as Notch, Hedgehog, Wnt/b-catenin, PI3K/Akt, NF-kB, BMP and TGF-beta and their maintenance and drug resistance, using various miRNAs, enhancement of CSCs apoptosis, differentiation therapy, blocking epithelial to mesenchymal transition and using different natural compounds. Recent studies have shown that cancer stem cells play major roles in target therapy on breast cancer. The new manipulation approaches of cancer stem cells can be used as target therapy of breast cancer that were highlighted for immunotherapy of cancer.