Daily increase of fat ingestion mediated via mu-opioid receptor signaling pathway.
Daily increase of fat ingestion mediated via mu-opioid receptor signaling pathway.
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通过 mu-阿片受体信号通路介导的脂肪摄入量每日增加。
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
T. Fushiki
中科院分区：
文献类型：
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作者：
T. Mizushige;S. Matsumura;T. Yoneda;S. Tsuzuki;Kazuo Inoue;T. Fushiki
我们研究了阿片受体（如mu和delta受体）在玉米油摄入5天重复治疗后玉米油食欲显著升高中的参与。用0.3%黄原胶乳化的5%玉米油在同一时间给大鼠灌胃20 min，连续5 d。5天后，对脂肪形成强烈的食欲，并且在3 mg/kg的剂量下，可被mu-1受体的选择性拮抗剂纳洛嗪抑制，但不被阿片δ受体的拮抗剂抑制。在第6天，在形成对玉米油的强烈食欲后，额外注射纳洛那嗪抑制了玉米油后0-30、30-60、60-90和90-150分钟的脂肪摄入，但阿片样物质δ受体拮抗剂没有。这些数据表明，阿片样物质μ受体参与了在向大鼠重复提供玉米油期间玉米油食欲的急剧升高。
We investigated the involvement of opioid receptors such as the mu and delta receptors in the predominant elevation of corn oil appetite just after 5-day repeated treatment of corn oil ingestion. Rats were given 5% corn oil emulsified with 0.3% xanthan gum for 20 min at the same hour for 5 consecutive days. A strong appetite for fat was formed after the 5 days presentation, and it was inhibited by naloxonazine, a selective antagonist of the mu-1 receptor, at doses of 3 mg/kg, but not by antagonists of the opioid delta receptor. In days 6, after the formation of a strong appetite for corn oil, an additional injection of naloxonazine suppressed fat intake 0-30, 30-60, 60-90 and 90-150 min after the presentation of the corn oil, but antagonists of the opioid delta receptor did not. These data suggested that the opioid mu receptor is involved in the sharp elevation of corn oil appetite during repeated presentation of corn oil to rats.
影响因子：
5.5
作者：
JOHNSON, SW;NORTH, RA
通讯作者：
NORTH, RA