Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside.
Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside.
复制标题
老年大鼠脊髓中神经肽含量降低：GM1 神经节苷脂的作用。
DOI：
10.1097/00001756-199902250-00013
复制
发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
Hadjiconstantinou,M
中科院分区：
文献类型：
--
作者：
Goettl,VM;Tejwani,GA;Neff,NH;Hadjiconstantinou,M
本研究观察了P物质(SP)、甲硫氨酸脑啡肽(Met-Enk)和强啡肽A(1-13)(Dyn A)在老龄SD大鼠脊髓中的分布及神经节苷脂GM1对其的影响。老年脊髓背角和腹角SP和Met-Enk均减少，Dyn A无明显变化。GML神经节苷脂(每天30 mg/kg ip，连续30天)可部分恢复腹角的神经肽缺失，但不能恢复背角的神经肽缺失。这些信息可能对理解与衰老相关的感觉和运动障碍，以及脊髓神经肽如何在衰老的脊髓中被放大很重要。
THIS study investigated the status of substance P (SP), methionine-enkephalin (Met-Enk) and dynorphin A (1-13)(Dyn A) in the spinal cord of aged Sprague–Dawley rats and the effect of GM1 ganglioside on these neuropeptides. SP and Met-Enk, but not Dyn A, were decreased in both dorsal and ventral horns of the aged spinal cord. Treatment with GMl ganglioside (30 mg/kg ip, daily for 30 days) restored, in part, the neuropeptide deficits in the ventral horns, but not in the dorsal horns. This information might be important for understanding the sensory and motor deficits associated with ageing, and how the spinal cord neuropeptides might be amplified in the aged spinal cord.