Decreases in the release of acetylcholine in vitro with low oxygen.
Decreases in the release of acetylcholine in vitro with low oxygen.
复制标题
低氧时体外乙酰胆碱的释放减少。
DOI：
10.1016/0006-2952(82)90246-5
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发表时间：
1982
影响因子：
5.8
通讯作者：
Peterson,C
中科院分区：
文献类型：
--
作者：
Gibson,GE;Peterson,C
吸入空气的O2含量的降低（缺氧）抑制了人和动物的更高的综合功能[1 -3]，但不降低脑能量储备[4-81]。因此，神经递质代谢的减少被认为是缺氧性脑功能障碍的可能分子基础[9]。缺氧损害乙酰胆碱（ACh）*[8，10，11]、血清素[12]、儿茶酚胺[13]和氨基酸[11，14，151]的体内合成，而它们的浓度保持不受影响。缺氧时合成的减少而水平没有相应的降低意味着缺氧损伤可能改变释放机制，
A decrease in the 02 content of the inspired air (hypoxia) depresses higher integrative function in man and animals [l-3] but does not reduce brain energy reserves [4-81. Thus, a decrease in the metabolism of neurotransmitters has been postulated as a possible molecular basis of hypoxic brain dysfunction[9]. Hypoxia impairs the in uiuo synthesis of acetycholine(ACh)*[8, 10, 11], serotonin [12], the catecholamines[13] and the amino acids [ll, 14,151, while their concentrations remain unaffected. The decrease in synthesis during hypoxia without a corresponding reduction in levels implies that hypoxic insults may alter release mechanisms and that the non-released neurotransmitter