BMI Affects the Relationship between Long Chain N-3 Polyunsaturated Fatty Acid Intake and Stroke Risk: a Meta-Analysis.
BMI Affects the Relationship between Long Chain N-3 Polyunsaturated Fatty Acid Intake and Stroke Risk: a Meta-Analysis.
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BMI 影响长链 N-3 多不饱和脂肪酸摄入量与中风风险之间的关系：荟萃分析。
DOI：
10.1038/srep14161
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发表时间：
2015-09-15
影响因子：
4.6
通讯作者：
Xie P
中科院分区：
文献类型：
--
作者：
Cheng P;Huang W;Bai S;Wu Y;Yu J;Zhu X;Qi Z;Shao W;Xie P
我们进行了一项荟萃分析，以阐明长链n-3多不饱和脂肪酸(PUFA)摄入与中风风险之间的关系。通过搜索截至2015年5月的在线数据库确定了相关研究。采用逆方差法对队列研究中最高与最低的对数相对危险度(RR)进行加权，得到合并相对危险度。14项前瞻性队列研究包括514,483名个体和9,065名中风患者。摄入长链n-3多不饱和脂肪酸的总中风风险的合并RR为0.87[95%可信区间(CI)，0.79-0.95]。分层分析显示，较高的长链n-3多不饱和脂肪酸摄入量与降低致命中风风险(RR = 0.84；95%CI，0.73-0.97)、降低BMI <； 24的中风风险(RR = 0.86；95%CI，0.75-0.98)以及降低女性的中风风险(RR = 0.81；95%CI，0.71-0.92)相关，但与BMI ≥ 24或男性的中风风险无关。这一荟萃分析显示，较高的长链n-3多不饱和脂肪酸摄入量与卒中发病率和死亡率呈负相关，BMI和性别是影响这一风险的关键因素。应鼓励个人控制体重，同时增加长链n-3多不饱和脂肪酸的摄入量。
We performed a meta-analysis to clarify the relationship between long chain n-3 polyunsaturated fatty acid (PUFA) intake and stroke risk. Relevant studies were identified by searching online databases through May 2015. Log relative risks (RRs) of the highest versus the lowest for cohort studies were weighed by the inverse variance method to obtain pooled RRs. Fourteen prospective cohort studies including 514,483 individuals and 9,065 strokes were included. The pooled RR of overall stroke risk for long chain n-3 PUFA intake was 0.87 [95% confidence interval (CI), 0.79–0.95]. Stratification analysis showed that higher long chain n-3 PUFAs intake was associated with reduced fatal stroke risk (RR = 0.84; 95% CI, 0.73–0.97), reduced stroke risk for BMI < 24 (RR = 0.86; 95% CI, 0.75–0.98) and reduced stroke risk for females (RR = 0.81; 95% CI, 0.71–0.92), but was not associated with stroke risk for either BMI ≥ 24 or men. This meta-analysis reveals that higher long chain n-3 PUFA intake is inversely associated with risk of stroke morbidity and mortality with BMI and sex as key factors influencing this risk. Individuals should be encouraged to manage their body weight while increasing their intake of long chain n-3 PUFAs.