Immunohistochemical localization of thrombomodulin in chorionic diseases of the uterus and choriocarcinoma of the stomach. A comparative study with the distribution of human chorionic gonadotropin
Immunohistochemical localization of thrombomodulin in chorionic diseases of the uterus and choriocarcinoma of the stomach. A comparative study with the distribution of human chorionic gonadotropin
复制标题
子宫绒毛膜疾病和胃绒毛膜癌中血栓调节蛋白的免疫组织化学定位。
作者：
Suguru Yonezawa;Takao Nakamura;Eiichi Sato;Ikuro Maruyama;Sadao Tanaka
血栓调节蛋白(TM)是一种新发现的蛋白质，它通过将凝血酶从促凝血酶转变为抗凝血剂而发挥强大的天然抗凝剂的功能。TM存在于人的血管和淋巴管内皮细胞及胎盘合体滋养层细胞上。在目前的研究中，我们通过免疫组织化学方法对子宫绒毛膜疾病和胃绒毛膜癌中的TM进行了定位。葡萄胎合体滋养层细胞含有TM。子宫绒毛膜癌肿瘤合体滋养层细胞中也有TM表达，但部分肿瘤合体滋养层细胞不表达TM。胃绒毛膜癌在肿瘤合体滋养层细胞中未见TM表达。在葡萄胎、子宫绒毛膜癌和胃绒毛膜癌中，合体滋养层细胞均表达人绒毛膜促性腺激素。
Thrombomodulin (TM) is a newly described protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. TM is found on endothelium of the blood and lymph vessels and on syncytiotrophoblast of the placenta in humans. In the current study, we localized TM by immunohistochemistry in chorionic diseases of the uterus and choriocarcinomas of the stomach. The syncytiotrophoblast of hydatidiform mole contained TM. Uterine choriocarcinoma also had TM in the neoplastic syncytiotrophoblastic cells, although some of the neoplastic syncytiotrophoblastic cells showed no TM expression. Gastric choriocarcinoma never showed TM expression in the neoplastic syncytiotrophoblastic cells. However, all of the syncytiotrophoblastic cells had human chorionic gonadotropin (hCG) in hydatidiform mole, uterine choriocarcinoma, and gastric choriocarcinoma.
影响因子：
13.6
作者：
Ma，Jian;Ren，Dianyun;Li，Lei
通讯作者：
Li，Lei
培养的人脐静脉内皮细胞和 A549 肺癌细胞中凝血酶-血栓调节蛋白复合物的周转。
DOI：
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发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Maruyama,I;Majerus,PW
通讯作者：
Majerus,PW