Observation of topological action potentials in engineered tissues
Observation of topological action potentials in engineered tissues
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DOI：
10.1038/s41567-022-01853-z
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发表时间：
2022-12
期刊：
影响因子：
19.6
通讯作者：
Hillel Ori;Marc Duque;Rebecca Frank Hayward;Colin Scheibner;He Tian;Gloria Ortiz;V. Vitelli;Adam E. Cohen
中科院分区：
文献类型：
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作者：
Hillel Ori;Marc Duque;Rebecca Frank Hayward;Colin Scheibner;He Tian;Gloria Ortiz;V. Vitelli;Adam E. Cohen
与任一组织本身相比，两个组织之间的界面可能具有非常不同的生物电特性。在这里，我们表明，由于通过间隙连接（电阻细胞间连接）的电流与界面两侧离子通道中的非线性电流-电压依赖性之间的相互作用，不可兴奋组织之间的界面可以是电兴奋的。我们的理论表明，这种拓扑鲁棒的兴奋性发生在比可以支持整体兴奋性的离子通道表达水平大得多的范围内。相应的界面动作电位可以引起局部钙浓度升高，可能为界面传感提供生物电机制。观察到的拓扑动作电位指出了电生理学和其他扩散耦合界面中其他类型的拓扑效应的可能性。
The interface between two tissues can have very different bioelectrical properties compared to either tissue on its own. Here we show that an interface between non-excitable tissues can be electrically excitable because of an interaction between the currents passing through the gap junctions—electrically resistive intercellular connections—and the non-linear current–voltage dependence in the ion channels on either side of the interface. Our theory shows that this topologically robust excitability occurs over a far larger range of ion channel expression levels than can support excitability in the bulk. The corresponding interfacial action potentials can cause local elevations in calcium concentration, possibly providing a bioelectrical mechanism for interface sensing. The observed topological action potentials point to the possibility of other types of topological effect in electrophysiology and at other diffusively coupled interfaces.