Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: The Ohasama Study
Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: The Ohasama Study
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DOI：
10.1291/hypres.27.551
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发表时间：
2004-08-01
影响因子：
5.4
通讯作者：
Ogihara, T
中科院分区：
文献类型：
--
作者：
Sugimoto, K;Katsuya, T;Ogihara, T
基因打靶研究表明，血管紧张素II 1型受体(AT1R)参与血压调节和血管紧张素II效应的调节。AT1R/A1166C基因的A1166C多态性与高加索人的高血压有关，但在日本人中不相关。这项名为Ohasama的研究的目的是研究AT1R/A1166C与日本普通人群中的高血压，特别是家族性BP之间的关系。Ohasama的研究是一项基于日本北部Ohasama镇的日本农村居民的队列研究。对研究方案和基因分析给予知情同意的受试者被招募。在早上起床后1小时内和晚上睡前分别测量了两次家庭血压。TaqMan聚合酶链式反应(TaqMan Polimerase Chain Reaction，PCR)方法明确检测AT1R/A1166C基因型(n=1,207)。AT1R/A1166C等位基因频率分布如下：AA 84%，AC 15%，CC 1%。AT1R基因型(AA、AC、CC)的基线特征几乎没有差异。在未接受降压药治疗的受试者(n=817)中，在调整混杂因素(年龄、性别、体重指数、当前吸烟习惯和当前饮酒)后，AT1R基因型之间的随意血压和家庭血压均无差异。调整混杂因素后，不同AT1R基因携带者患高血压的频率差异无统计学意义，但在高血压患者中，AC和CC基因的频率高于正常血压者。我们的数据提示AT1R/A1166C多态不是日本人高血压的主要遗传易感因素。
Gene targeting approaches have suggested that the angiotensin II type 1 receptor (AT1R) is involved in blood pressure (BP) regulation and modulation of the effect of angiotensin II. The A1166C polymorphism of the AT1 receptor gene (AT1R/A1166C) is associated with hypertension in Caucasians, but not in Japanese. The goal of this study, the Ohasama Study, was to examine the association between AT1R/A1166C and hypertension, especially home BP, in the Japanese general population. The Ohasama Study was a cohort study based on Japanese rural residents of Ohasama Town in the northern part of Japan. Subjects who gave informed consent to the study protocol and genetic analysis were recruited. Home BP was measured twice in the morning within 1 h of waking up and in the evening just before going to bed. The TaqMan polimerase chain reaction (PCR) method clearly determined AT1R/A1166C genotypes (n = 1,207). The genotype distribution of AT1R/A1166C was as follows: AA 84%; AC 15%; CC 1%. There was almost no difference in baseline characteristics among the AT1R genotypes (AA, AC, CC). In the subjects not receiving antihypertensive medication (n = 817), both casual BP and home BP were not different among the AT1R genotypes after adjusting for confounding factors (age, sex, body mass index, current smoking habit and current alcohol consumption). The frequency of hypertension showed no difference among AT1R genotypes after adjusting for confounding factors, though the AC and CC genotypes were more frequent in hypertensives than in normotensives. Our data suggested that the AT1R/A1166C polymorphism is not a major genetic predisposing factor for hypertension in Japanese.