Association of initial antipsychotic response to clozapine and long-term weight gain
Association of initial antipsychotic response to clozapine and long-term weight gain
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DOI：
10.1176/appi.ajp.163.7.1276
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发表时间：
2006-07-01
影响因子：
17.7
通讯作者：
Chou, Pesus
中科院分区：
文献类型：
--
作者：
Bai, Ya Mei;Lin, Chao-Cheng;Chou, Pesus
目的：本研究的目的是测试氯氮平的初始抗精神病反应是否与随后的体重变化有关。方法：对96例住院精神分裂症患者进行8年回顾性分析。分析每月体重变化、初始临床反应、年龄、性别、氯氮平剂量以及同时使用情绪稳定剂和其他抗精神病药物的数据。结果：55例（57.3%）患者在整个8年期间接受氯氮平治疗；这些受试者的平均体重增加了11.7 kg （SD=1.6）。这些患者中有17例（30.9%）具有显著的初始临床反应（前14个月CGI改善评分为1或2），体重增加（13.8 kg [SD=8.4]）明显多于38例无显著初始反应的患者（4.5 kg [SD=12.0]）。多元线性回归分析显示显著的初始临床反应和较低的基线体重指数与显著的体重增加相关。结论：结果显示氯氮平的初始抗精神病反应与随后8年的长期体重增加有关。
Objective: The aim of this study was to test whether the initial antipsychotic response to clozapine is related to subsequent weight change.Method: This study was an 8-year retrospective chart review of 96 hospitalized patients with schizophrenia. Data on monthly weight change, initial clinical response, age, gender, clozapine dose, and concomitant use of mood stabilizers and other antipsychotics were analyzed.Results: Fifty-five (57.3%) of the patients received clozapine over the entire 8-year period; these subjects experienced an average weight gain of 11.7 kg (SD=1.6). Seventeen of these patients (30.9%) who had a significant initial clinical response (CGI improvement rating of 1 or 2 during the first 14 months) gained significantly more weight (13.8 kg [SD=8.4]) than did the 38 patients without a significant initial response (4.5 kg [SD=12.0]). Multiple linear regression analysis showed significant initial clinical response and lower baseline body mass index were associated with significantly more weight gain.Conclusions: The results show that initial antipsychotic response to clozapine is associated with subsequent long-term weight gain as measured over 8 years.