Long term exposure to NO2 and diabetes incidence in the Black Women's Health Study.
Long term exposure to NO2 and diabetes incidence in the Black Women's Health Study.
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DOI：
10.1016/j.envres.2016.04.021
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发表时间：
2016-07
影响因子：
8.3
通讯作者：
Jerrett M
中科院分区：
文献类型：
--
作者：
Coogan PF;White LF;Yu J;Burnett RT;Marshall JD;Seto E;Brook RD;Palmer JR;Rosenberg L;Jerrett M
While laboratory studies show that air pollutants can potentiate insulin resistance, the epidemiologic evidence regarding the association of air pollution with diabetes incidence is conflicting. The purpose of the present study was to assess the association of the traffic-related nitrogen dioxide (NO2) with the incidence of diabetes in a longitudinal cohort study of African American women. We used Cox proportional hazards models to calculate hazard ratios and 95% confidence intervals (CI) for diabetes associated with exposure to NO2 among 43,003 participants in the Black Women's Health Study (BWHS). Pollutant levels at participant residential locations were estimated with 1) a land use regression model for participants living in 56 metropolitan areas, and 2) a dispersion model for participants living in 27 of the cities. From 1995-2011, 4387 cases of diabetes occurred. The hazard ratios per interquartile range of NO2 (9.7 ppb), adjusted for age, metropolitan area, education, vigorous exercise, body mass index, smoking, and diet, were 0.96 (95% CI 0.88-1.06) using the land use regression model estimates and 0.94 (95% CI 0.80, 1.10) using the dispersion model estimates. The present results do not support the hypothesis that exposure to NO2 contributes to diabetes incidence in African American women.
