Role of diminished renal function in cardiovascular mortality - Marker or pathogenetic factor?
Role of diminished renal function in cardiovascular mortality - Marker or pathogenetic factor?
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DOI：
10.1016/j.jacc.2005.07.067
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发表时间：
2006-01-03
影响因子：
24
通讯作者：
Schrier, RW
中科院分区：
文献类型：
--
作者：
Schrier, RW
心脏和肾脏之间的相互作用最近一直是人们关注的焦点，因为流行病学证据表明，即使是轻度的肾功能恶化也是充血性心力衰竭、心肌梗死和心血管手术患者预后不良的重要危险因素。肾功能恶化可能是心脏和压力感受器功能障碍的结果，也可能主要是由内在肾脏疾病引起的。本文综述了肾脏不仅作为心肾综合征的标志物，而且作为心肾综合征的致病因素的作用，无论是原发性心脏病或原发性肾脏疾病或两者都是随后的病理生理事件的发起者。
The interactions between the heart and the kidney recently have been the focus of intense interest because of epidemiological evidence indicating that even mild deterioration of renal function is an important risk factor for poor outcome in patients with congestive heart failure, myocardial infarction, and cardiovascular surgery. Kidney function deterioration may, be a consequence of cardiac and baroreceptor dysunction or may be primarily, caused by intrinsic kidney, disease. This review provides a comprehensive analysis of the role of the kidney not only as a marker but also as a pathogenic factor in cardiorenal syndromes, whether primary heart or primary kidney disease or both are the initiators of the subsequent pathophysiological events.