Inflamma-miRs in Aging and Breast Cancer: Are They Reliable Players?
Inflamma-miRs in Aging and Breast Cancer: Are They Reliable Players?
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DOI：
10.3389/fmed.2015.00085
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发表时间：
2015
影响因子：
3.9
通讯作者：
Berindan-Neagoe I
中科院分区：
文献类型：
--
作者：
Cătană CS;Calin GA;Berindan-Neagoe I
人类衰老的特征是慢性低度炎症，称为"炎症"。持续的低水平炎症在乳腺癌的所有阶段中也起着关键作用，因为"炎症"是癌症和衰老之间通过受特定miR高度影响的NF-κ B途径的潜在联系。微RNA（micro-RNAs，miRNAs）是一类在转录后水平负调控基因表达的小分子非编码RNA。炎症-miR已经涉及免疫和炎症反应的调节。它们的异常表达有助于在正常衰老和主要年龄相关疾病（ARDs）中记录的慢性促炎状态，炎症在这两种情况下都是显著的死亡风险因素。然而，炎症的正确诊断很难做出，其对负面健康结果的隐藏贡献仍然未知。该方法学工作流程旨在定义有关炎症的关键未回答问题，这些问题可用于澄清血清和细胞系中与衰老相关的miRNA及其靶点，从而证实它们在衰老和乳腺癌肿瘤发生中的作用。此外，我们的目标是强调癌症和衰老过程的促炎机制与某些miRNA在细胞衰老（CS）中的精确功能之间的联系。此外，miRNA和癌症基因代表了新的治疗发现的基础，表明癌症和ARDs基因都是参与CS的可能候选者，反之亦然。我们的目标是获得一个集中的审查，可以促进未来的方法，在调查的机制，miRNA控制衰老过程中，作为有效的ARDs炎症生物标志物。了解炎症-miR的来源和调节以及鉴定其特异性靶基因可以增强其治疗潜力。
Human aging is characterized by chronic low-grade inflammation known as “inflammaging.” Persistent low-level inflammation also plays a key role in all stages of breast cancer since “inflammaging” is the potential link between cancer and aging through NF-kB pathways highly influenced by specific miRs. Micro-RNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at a posttranscriptional level. Inflamma-miRs have been implicated in the regulation of immune and inflammatory responses. Their abnormal expression contributes to the chronic pro-inflammatory status documented in normal aging and major age-related diseases (ARDs), inflammaging being a significant mortality risk factor in both cases. Nevertheless, the correct diagnosis of inflammaging is difficult to make and its hidden contribution to negative health outcomes remains unknown. This methodological work flow was aimed at defining crucial unanswered questions about inflammaging that can be used to clarify aging-related miRNAs in serum and cell lines as well as their targets, thus confirming their role in aging and breast cancer tumorigenesis. Moreover, we aim to highlight the links between the pro-inflammatory mechanism underlying the cancer and aging processes and the precise function of certain miRNAs in cellular senescence (CS). In addition, miRNAs and cancer genes represent the basis for new therapeutic findings indicating that both cancer and ARDs genes are possible candidates involved in CS and vice versa. Our goal is to obtain a focused review that could facilitate future approaches in the investigation of the mechanisms by which miRNAs control the aging process by acting as efficient ARDs inflammatory biomarkers. An understanding of the sources and modulation of inflamma-miRs along with the identification of their specific target genes could enhance their therapeutic potential.