The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin.
The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin.
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DOI：
10.2174/156802608783378828
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发表时间：
2008
影响因子：
3.4
通讯作者：
Maoquan Zhou;G. O'Doherty
中科院分区：
文献类型：
--
作者：
Maoquan Zhou;G. O'Doherty
To address the medicinal chemist's need for new synthetic methods for the preparation of unnatural carbohydrates, a new de novo method for carbohydrate synthesis has been developed. These routes use a palladium catalyzed glycosylation reaction to stereoselectively control the anomeric center and subsequent diastereoselective post glycosylation to install the remaining sugar stereocenters. The utility of this method was demonstrated by the syntheses and biological evaluation of several digitoxin oligosaccharide analogues.
