Repopulation of liver endothelium by bone-marrow-derived cells
Repopulation of liver endothelium by bone-marrow-derived cells
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DOI：
10.1016/s0140-6736(00)04217-3
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发表时间：
2001-03-24
期刊：
影响因子：
168.9
通讯作者：
Williams, GM
中科院分区：
文献类型：
--
作者：
Gao, ZH;McAlister, VC;Williams, GM
同种异体肝移植相对于其他器官的免疫学优势的机制尚不完全清楚。我们使用Y染色体上重复单元的分子探针，来识别接受女性供体肝移植的男性的针活检样本中越来越多的男性肝静脉内皮细胞，我们还在男性到女性小鼠骨髓移植模型中显示了骨髓衍生细胞的肝内皮细胞的再增殖。我们得出的结论是，肝脏具有独特的静脉内皮，其特征是被骨髓来源的细胞更新和替换。
the mechanism underlying the immunological advantage of hepatic allografts relative to other organs is incompletely understood. We used molecular probes for the repetitive units on the Y chromosome, to identify an increasing number of male liver venous endothelial cells In needle biopsy samples of men who received female donor liver grafts, We have also shown repopulation of liver endothelium by bone marrow derived cells in a male to female mouse bone marrow transplant model. We conclude that the liver has unique venous endothelium characterised by turnover and replacement by bone marrow derived cells.