Fabrication of macroporous carbonate apatite foam by hydrothermal conversion of α-tricalcium phosphate in carbonate solutions
Fabrication of macroporous carbonate apatite foam by hydrothermal conversion of α-tricalcium phosphate in carbonate solutions
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DOI：
10.1002/jbm.a.31620
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发表时间：
2008-12-15
影响因子：
4.9
通讯作者：
Ishikawa, K.
中科院分区：
文献类型：
--
作者：
Wakae, H.;Takeuchi, A.;Ishikawa, K.
骨由矿物相（碳酸磷灰石）和有机相（主要是胶原）组成。松质骨的特征在于组织向内生长和营养骨细胞所必需的互连孔隙。本研究的目的是通过在碳酸盐溶液中水热转化α-TCP泡沫来制备具有互连孔隙的大孔碳酸磷灰石（CAP）块体，作为潜在的骨替代生物材料。大孔CAP的制备分两步完成：（1）使用聚氨酯泡沫作为模板制备α-TCP泡沫，和（2）在不同浓度的碳酸铵溶液存在下在200 ° C下水热转化α-TCP泡沫。所得CAP泡沫的最大碳酸盐含量为约7.4重量%。CAP泡沫的平均孔隙率高达93体积%。以这种方式制备的大孔CAP块或颗粒在矿物质组成和具有骨传导性和组织向内生长所需的互连大孔隙方面具有与骨相似的性质。CAP泡沫材料具有良好的复合性和相互连通的大孔结构，是理想的骨修复材料和组织工程支架材料。(C)2008 Wiley Periodicals，Inc. J Biomed Mater Res 87A：957-963，2008
Bone consists of a mineral phase (carbonate apatite) and an organic phase (principally collagen). Cancellous bone is characterized by interconnecting porosity necessary for tissue ingrowth and nourishment of bone cells. The purpose of the present study was to fabricate macroporous carbonate apatite (CAP) blocks with interconnecting porosity as potential bone substitute biomaterials by hydrothermal conversion of alpha-TCP foam in carbonate solution. The fabrication of the macroporous CAP was accomplished in two steps: (1) preparation of alpha-TCP foams using polyurethane foams as templates, and (2) hydrothermal conversion at 200 degrees C of alpha-TCP foam in the presence of ammonium carbonate solutions of different concentrations. The maximum carbonate content of the resultant CAP foam was approximately 7.4 wt %. The mean porosity of the CAP foam was as high as 93 vol %. The macroporous CAP blocks or granules prepared in this manner has properties similar to that of bone in mineral composition and in having interconnecting macroporosity necessary for osteoconductivity and tissue ingrowth. On the basis of composition and interconnecting macroporosity, the CAP foam materials Could be ideal biomaterials for bone repair and as scaffolds for tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 87A: 957-963, 2008