Reasons for the emergence of antibiotic resistance
Reasons for the emergence of antibiotic resistance
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DOI：
10.1097/00000441-199601000-00003
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发表时间：
1996-01-01
影响因子：
3.1
通讯作者：
McGowan, JE
中科院分区：
文献类型：
--
作者：
Tenover, FC;McGowan, JE
许多不同种类的细菌，包括那些在人类中引起疾病的细菌，抵抗抗微生物剂的抑制作用的能力已经成为一个全球性问题。耐药性不仅在医院病原体中继续传播，而且在几个关键的社区获得性生物体中也继续传播。对这种抗药性生物的适当控制措施部分取决于产生抗药性的途径。不幸的是，这些途径在不同的生物体和环境中有很大的不同。此外，虽然耐药微生物的流行病学有时与同类敏感微生物的流行病学相似，但在某些情况下可能完全不同。在这篇文章中，作者强调了导致细菌耐药性发展的一些途径，抗菌药物使用的重要性，以及这些机制与医院和社区环境中控制耐药细菌措施的相关性。
The ability of many different species of bacteria, including those that cause disease in humans, to resist the inhibitory action of antimicrobial agents has become a global problem. Resistance continues to spread not only in nosocomial pathogens but in several key community-acquired organisms as well. Appropriate control measures for such resistant organisms depend in part on the pathways by which resistance has arisen. Unfortunately, these pathways differ greatly from organism to organism and setting to setting. In addition, although the epidemiology of resistant organisms sometimes is similar to that of susceptible organisms of the same kind, in some situations it may be quite different. In this article, the authors highlight some of the pathways leading to the development of resistance in bacteria, the importance of antimicrobial use, and the relevance of these mechanisms to measures for the control of resistant bacteria in hospital and community settings.