Harnessing transposable elements for cancer therapy.

Harnessing transposable elements for cancer therapy.
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利用转座元件进行癌症治疗。

DOI:
10.1016/j.trecan.2023.05.005
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发表时间:
2023
期刊:
影响因子:
18.4
通讯作者:
Han,Leng
Han,Leng
中科院分区:
医学1区
文献类型:
--
作者:
Liu,Yuan;Han,Leng

文献摘要

相似文献

转座元件(TES)可以在基因组内移动,并在癌症的发展中发挥重要作用。Shah等人最近发现TES具有调节潜力,并且肿瘤特异性TE基因嵌合事件可以作为通用的癌症生物标记物和癌症免疫治疗的靶点。
Transposable elements (TEs) can move within the genome and can have a significant role in cancer development. Shah et al.recently identified that TEs have regulatory potentials and that tumor-specific TE–gene chimeric events that produce new isoforms of proteins could serve as universal cancer biomarkers and targets for cancer immunotherapy.