Human and murine Th17
Human and murine Th17
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DOI：
10.1097/coh.0b013e32833647c2
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发表时间：
2010-03-01
影响因子：
4.1
通讯作者：
Romagnani, Sergio
中科院分区：
文献类型：
--
作者：
Annunziato, Francesco;Cosmi, Lorenzo;Romagnani, Sergio
综述的目的本综述的目的是总结在人和小鼠Th 17细胞的表型和功能特性领域的最新发现。最近的发现人Th 17细胞表达CD 161，并且仅来源于存在于脐带血和新生儿胸腺中的CD 161（+）前体，对IL-1 β和IL-23的联合活性作出反应。相反，鼠Th 17细胞不表达CD 161，并且起源于对IL-6、IL-1和TGF-β的应答，即使后者最近被证明是可耐受的。在小鼠中的研究最初表明，Th 17细胞是自身免疫性疾病中的致病细胞，而Th 1细胞可能表现为保护性。随后，对人体的研究证明了Th 17细胞在IL-12存在下活化时转变为Th 1细胞的能力。Th 17到Th 1细胞的可塑性现在已经在小鼠中得到证实，其中发现Th 17细胞仅在它们转变为Th 1细胞时才在某些自身免疫性疾病模型中成为致病性的。
Purpose of reviewThe purpose of this review is to summarize the most recent discoveries in the field of phenotypic and functional characterization of human and murine Th17 cells.Recent findingsHuman Th17 cells express CD161 and exclusively originate from CD161(+) precursors present in umbilical cord blood and newborn thymus in response to the combined activity of IL-1 beta and IL-23. On the contrary, murine Th17 cells do not express CD161 and originate in response to IL-6, IL-1, and TGF-beta, even if the latter has recently been shown to be dispensable. Studies in mice have initially suggested that Th17 cells are the pathogenic cells in autoimmune disorders, whereas Th1 cells may behave rather as protective. Studies in humans have subsequently demonstrated the capacity of Th17 cells to shift to Th1 cells when activated in the presence of IL-12. The plasticity of Th17 to Th1 cells has been now confirmed in mice, where it was found that Th17 cells become pathogenic in some models of autoimmune diseases only when they shift to Th1 cells.SummaryThe issue of Th17 plasticity is of fundamental importance for those researchers directed to manipulate immune responses in therapeutically useful manner.