NG-nitro-L-arginine prevents morphine tolerance.
NG-nitro-L-arginine prevents morphine tolerance.
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NG-硝基-L-精氨酸可防止吗啡耐受。
DOI：
10.1016/0014-2999(92)90732-j
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发表时间：
1992
影响因子：
5
通讯作者：
Pasternak,GW
中科院分区：
文献类型：
--
作者：
Kolesnikov,YA;Pick,CG;Pasternak,GW
NMDA受体拮抗剂，如MK-801，可以防止对吗啡的耐受。由于许多NMDA作用涉及一氧化氮的产生，我们研究了一氧化氮合酶抑制剂对吗啡耐受性的影响。吗啡(5 mg/kg皮下注射)的镇痛反应。在5天内从幼稚动物的60%减少到0%。将NG-硝基-L-精氨酸(每天8毫克/公斤)与吗啡合用，可防止在至少11天内表现出明显的耐受性。这些结果表明，吗啡耐受涉及NMDA受体的激活，随后一氧化氮的释放。
NMDA receptor antagonists, such as MK-801, prevent the development of tolerance to morphine. Since many NMDA actions involve the production of nitric oxide, we examined the effects of a nitric oxide synthase inhibitor on morphine tolerance. The analgesic response to morphine (5 mg/kg s.c.) given daily diminishes from 60% in naive animals to 0% within 5 days. Coadministration of NG-nitro-L-arginine (8 mg/kg per day) along with morphine prevents the demonstration of appreciable tolerance for at least 11 days. These results suggest that morphine tolerance involves the activation of NMDA receptors followed by the subsequent release of nitric oxide.