Nestin as a marker of cancer stem cells.
Nestin as a marker of cancer stem cells.
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DOI：
10.1111/cas.12691
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发表时间：
2015-07
期刊：
影响因子：
5.7
通讯作者：
Veselska R
中科院分区：
文献类型：
--
作者：
Neradil J;Veselska R
在过去的十年中，癌症干细胞（CSCs）在恶性疾病病理学中的关键作用得到了广泛的研究。巢蛋白是一种VI类中间丝蛋白，最初在发育过程中的神经干细胞中检测到。还报道了其在各种病理条件下在不同组织中的表达。具体地说，巢蛋白已被证明在各种人类恶性肿瘤的转化细胞中表达，并且其表达与一些疾病的临床过程之间的相关性已被证明。此外，巢蛋白与其他干细胞标志物的共表达被描述为CSC表型，随后使用致瘤性测定进行了验证。本综述的主要目的是总结最近的研究结果有关巢蛋白在CSC中的表达，其可能的作用，CSC表型，特别是在自我更新的能力，其效用作为一个假定的标记CSC。巢蛋白在人类多种恶性肿瘤的转化细胞中均有表达，并且其表达与某些疾病的临床病程相关。此外，巢蛋白与其他干细胞标志物的共表达被描述为CSC表型，随后使用致瘤性测定来验证。本综述的主要目的是总结最近的研究结果有关巢蛋白在CSC中的表达，其可能的作用，CSC表型，特别是在自我更新的能力，其效用作为一个假定的标记CSC。
The crucial role of cancer stem cells (CSCs) in the pathology of malignant diseases has been extensively studied during the last decade. Nestin, a class VI intermediate filament protein, was originally detected in neural stem cells during development. Its expression has also been reported in different tissues under various pathological conditions. Specifically, nestin has been shown to be expressed in transformed cells of various human malignancies, and a correlation between its expression and the clinical course of some diseases has been proved. Furthermore, the coexpression of nestin with other stem cell markers was described as a CSC phenotype that was subsequently verified using tumorigenicity assays. The primary aim of this review is to summarize the recent findings regarding nestin expression in CSCs, its possible role in CSC phenotypes, particularly with respect to capacity for self-renewal, and its utility as a putative marker of CSCs. Nestin has been shown to be expressed in transformed cells of various human malignancies, and a correlation between its expression and the clinical course of some diseases has been proved. Furthermore, the co-expression of nestin with other stem cell markers was described as a CSC phenotype that was subsequently verified using tumorigenicity assays. The primary aim of this review is to summarize the recent findings regarding nestin expression in CSCs, its possible role in CSC phenotypes, particularly with respect to capacity for self-renewal, and its utility as a putative marker of CSCs.