Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis
Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis
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DOI：
10.1111/jgh.12948
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发表时间：
2015-09-01
影响因子：
4.1
通讯作者：
Aizawa, Yoshio
中科院分区：
文献类型：
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作者：
Abe, Hiroshi;Aida, Yuta;Aizawa, Yoshio
背景与目的探讨乙醛脱氢酶2（ALDH 2）、乙醇脱氢酶1 B（ADH 1 B）基因多态性和乙醇消耗量对无慢性B和C型肝炎病毒感染的酒精性肝硬化患者发生肝细胞癌（HCC）的影响方法在236例新诊断的非B非C型酒精性肝硬化患者中，67例诊断为HCC，其余169例为非HCC。在肝癌患者中研究基因多态性与肝癌发生的关系（HCC组，n=67）和无HCC（非HCC组，n=67）使用年龄、性别和糖尿病患病率的倾向评分。肝细胞癌组消耗时间明显长于非肝细胞癌组（P =0.003）。在134例完全匹配的患者中，113例（84.3%）为ALDH 2 *1/*1型，21例（15.7%）为ALDH 2 *1/*2型。在肝癌的发生中，饮酒时间长（P=0.007）和携带ALDH 2 *1/*2基因型（P=0.026）是独立的影响因素，而ADH 1B基因多态性与肝癌的发生无关。ALDH 2 *1/*1基因型患者肝细胞癌组酒精消耗时间显著长于非肝细胞癌组（P=0.0005），而ALDH 2 *1/*2基因型患者酒精消耗量无差异。在肝细胞癌组中，ALDH 2 *1/*1基因型患者的每日（P= 3.78 × 10 - 6）和累积（P= 4.89 × 10 - 6）乙醇消耗量显著高于ALDH 2 *1/*2基因型患者。
Background and AimWe aimed to clarify the influences of aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 1B (ADH1B) polymorphisms, and ethanol consumption profile to hepatocellular carcinoma (HCC) development in alcoholic liver cirrhosis without chronic hepatitis B and C virus infection (non-B non-C).MethodsOf 236 freshly diagnosed non-B non-C alcoholic liver cirrhosis patients, 67 were diagnosed as HCC and the remaining 169 as not having HCC. The relationship between the genetic polymorphisms and development to HCC were evaluated in well-matched patients with HCC (HCC group, n=67) and without HCC (non-HCC group, n=67) using propensity scores in age, sex, and prevalence of diabetes mellitus.ResultsDaily amount of ethanol consumption was significantly lower (P=0.005), and consumptive period was significantly longer (P=0.003) in HCC group than non-HCC group. Of 134 well-matched patients, 113 (84.3%) had ALDH2*1/*1 genotype and 21 (15.7%) had ALDH2*1/*2 genotype. In HCC development, consumptive long period (P=0.007) and carrying ALDH2*1/*2 genotype (P=0.026) were identified as significant factors independently participated, while there was no relation to ADH1B polymorphism. In addition, consumptive period was significantly longer in HCC group than non-HCC group in ALDH2*1/*1 genotype patients (P=0.0005), while there was no difference in profile of ethanol consumption in ALDH2*1/*2 genotype patients. Among HCC group, daily (P=3.78x10(-6)) and cumulative amount (P=4.89x10(-6)) of ethanol consumption were significantly higher in ALDH2*1/*1 genotype patients than ALDH2*1/*2 genotype patients.ConclusionIn alcoholic liver cirrhosis, investigations of ALDH2 polymorphism and ethanol consumption profile are useful for prediction of HCC development.