PCNA CYCLIN AND P-GLYCOPROTEIN AS PROGNOSTIC FACTORS IN LOCALLY ADVANCED BREAST-CANCER - AN IMMUNOHISTOCHEMICAL, RETROSPECTIVE STUDY
PCNA CYCLIN AND P-GLYCOPROTEIN AS PROGNOSTIC FACTORS IN LOCALLY ADVANCED BREAST-CANCER - AN IMMUNOHISTOCHEMICAL, RETROSPECTIVE STUDY
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DOI：
10.1177/030089169307900312
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发表时间：
1993-06-30
期刊：
影响因子：
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通讯作者：
CASCIONE, F
中科院分区：
文献类型：
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作者：
BOTTI, G;CHIAPPETTA, G;CASCIONE, F
目的和背景：本研究的目的是回顾性地确定两种侵袭性生物标志物P-糖蛋白（P-gp）和PCNA/细胞周期蛋白（PCNA）的免疫组化表达是否与局部晚期乳腺癌的化疗反应和预后有关。研究方法：应用PC 10单克隆抗体和C-219单克隆抗体分别测定25例术前化疗的局部晚期乳腺癌患者的增殖指数（PCNA）和P-糖蛋白（P-gp）。结果：P-gp和PCNA在76%和100%的乳腺癌中表达。P-gp高表达的病例与化疗敏感性无关，所有P-gp阴性的病例均表现出最佳的化疗反应。P-gp和PCNA在发生局部或远处转移的患者中均呈高表达。无复发与阴性或低P-gp评分相关。结论：P-gp高表达与化疗疗效差、无病生存期短有关。高PCNA评分对预测化疗敏感性或生存率无显著意义。
Aims and Background: The alm of the present study was to determine, retrospectively, whether the immunohistochemical expression of two biologic markers of aggressivity, P-glycoprotein (P-gp) and PCNA/cyclin (PCNA), could be related to response to chemotherapy and prognosis in locally advanced breast cancer. Methods: PC 10 Mab was used to determine the proliferation index (PCNA) and C-219 Mab to determine P-gp in 25 locally advanced breast carcinomas subjected to preoperative chemotherapy with MDR-related drugs. Results: P-gp and PCNA were expressed in 76 % and 100 % of the tumors, respectively. No case of high P-gp expression was associated with good chemosensitivity, and all P-gp-negative cases showed the best chemotherapeutic response. P-gp and PCNA were both highly expressed in patients who developed local-regional or distant metastases. No recurrence was associated with a negative or low P-gp score. Conclusions: Statistical analysis showed that high P-gp expression was related to a poor response to chemotherapy and a short disease-free survival. A high PCNA score was not found to be significant for predicting chemosensitivity or survival.