Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements
Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements
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DOI：
10.1007/bf03021622
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发表时间：
2006-07-01
期刊：
影响因子：
--
通讯作者：
Ozcan, B
中科院分区：
文献类型：
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作者：
Gurbet, A;Basagan-Mogol, E;Ozcan, B
目的：这项前瞻性、随机、双盲研究旨在评估术中输注右美托咪定是否可提供有效的术后镇痛。术后疼痛评分和吗啡的消耗量进行了比较，在治疗组和安慰剂组，这两个接受病人控制的吗啡后，全腹hectors.Methods：50名妇女被随机分为两组。D组（n = 25）接受负荷剂量右美托咪定1 μ g. kg（-1）静脉注射，然后以0.5 μ g（.）kg（-1.）HR（-1）在整个操作过程中。P组（n = 25）接受容量匹配的推注和输注安慰剂（0.9%生理盐水）。对于每例患者，术中和术后48小时记录心率、外周血氧饱和度、收缩压和舒张压。术后患者使用患者自控镇痛装置接受大剂量吗啡。总吗啡消耗量，疼痛评分和镇静评分记录的第一个48小时（两个小时在麻醉后监护室和46小时的病房）。在整个48小时观察期的所有相应时间，两组之间的疼痛和镇静评分也相似。D组患者在麻醉后监护室和病房的吗啡消耗量显著减少（分别为P < 0.05和P < 0.01）。结论：右美托咪定用于腹部手术后镇痛效果良好，可减少术后吗啡用量，且不增加不良反应的发生率。
Purpose: This prospective, randomized, double-blind study was designed to assess whether intraoperative infusion of dexmedetomidine provides effective postoperative analgesia. Postoperative pain scores and morphine consumption were compared in a treated group and a placebo group, both of which received patient-controlled morphine after total abdominal hysterectomy.Methods: Fifty women were randomly assigned to two groups. Group D (n = 25) received a loading dose of dexmedetomidine 1 mu g(.)kg(-1) iv during induction of anesthesia, followed by a continuous infusion at a rate of 0.5 mu g(.)kg(-1.)hr(-1) throughout the operation. Group P (n = 25) received a volume-matched bolus and infusion of placebo (0.9% saline). For each case, heart rate, peripheral oxygen saturation, and systolic and diastolic blood pressure were recorded intraoperatively and for 48 hr postoperatively. Patients used a patient-controlled analgesia device to receive bolus doses of morphine after surgery. Total morphine consumption, pain scores, and sedation scores were recorded for the first 48 hr (two hours in the postanesthesia care unit and 46 hr on the ward).Results: The groups were similar with respect to mean times to extubation of the trachea. Pain and sedation scores were also similar between groups at all corresponding times throughout the 48-hr period of observation. Group D patients consumed significantly less morphine in the postanesthesia care unit and on the ward (P < 0.05 and P < 0.01, respectively). Fewer patients in Group D experienced itching or nausea/vomiting (P < 0.05).Conclusion: Continuous iv dexmedetomidine during abdominal surgery provides effective postoperative analgesia, and reduces postoperative morphine requirements without increasing the incidence of side effects.