Intra-subject variability in attention-deficit hyperactivity disorder
Intra-subject variability in attention-deficit hyperactivity disorder
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DOI：
10.1016/j.biopsych.2006.04.003
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发表时间：
2006-11-15
影响因子：
10.6
通讯作者：
Peper, Martin
中科院分区：
文献类型：
--
作者：
Klein, Christoph;Wendling, Katharina;Peper, Martin
背景。本研究基于对神经心理学注意力缺陷多动障碍（ADHD）文献的全面调查，并首次采用连续表现测试、Go-NoGo任务、停止信号任务和N-back任务，对ADHD患者与健康对照组的不同受试者内变异性（ISV）参数进行了心理测量分析。方法：对57例ADHD患者和53例年龄、性别匹配的对照组进行统计分析。使用不同的参数来描述反应时间分布的集中趋势（算术平均值、中位数）、离散度（标准差、变异系数、连续方差）、形状（偏度、过剩）以及误差（委托和遗漏）。组间比较显示，到目前为止，分散度测量的效果最强，其次是集中趋势测量，以及委员会误差。ISV的统计控制大大减少了其他措施的组间差异。一个（患者）或两个（对照）主成分解释了个体内部变异中67%的个体间差异。结论：结果表明，在各种神经心理学测试中，ISV的测量最有助于群体区分，而集中倾向和误差测量的增量有效性有限。此外，ISV的增加可能是ADHD的单一结构。
Background. This study is based on a comprehensive survey of the neuropsychological attention-deficit hyperactivity disorder (ADHD) literature and presents the first psychometric analyses of different parameters of intra-subject variability (ISV) in patient, with ADHD compared to healthy controls, using the Continuous Performance Test, a Go-NoGo task, a Stop Signal Task, as well as N-back tasks.Methods: Data of 57 patients with ADHD and 53 age- and gender-matched controls were available for statistical analysis. Different parameters were used to describe central tendency (arithmetic mean, median), dispersion (standard deviation, coefficient of variation, consecutive variance), and shape (skewness, excess) of reaction time distributions, as well as errors (commissions and omissions).Results. Group comparisons revealed by far the strongest effect sizes for measures of dispersion, followed by measures of central tendency, and by commission errors. Statistical control of ISV reduced group differences in the other measures substantialy. One (patients) or two (controls) principal components explained tip to 67% of the inter-individual differences in intra-individual variability.Conclusions: Results suggest that, across a variety of neuropychological tests, measures of ISV contribute best to group discrimination, with limited incremental validity of measures of central tendency and errors. Furthermore, increased ISV might be a unitary construct in ADHD.