New murine model of bronchopneumonia due to cell-bound Haemophilus influenzae.
New murine model of bronchopneumonia due to cell-bound Haemophilus influenzae.
复制标题
由细胞结合的流感嗜血杆菌引起的支气管肺炎的新小鼠模型。
DOI：
10.1093/infdis/175.1.205
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Keizo Yamaguchi
中科院分区：
文献类型：
--
作者：
S. Miyazaki;Tetsuo Nunoya;T. Matsumoto;K. Tateda;Keizo Yamaguchi
This murine model of nontypeable (unencapsulated) Haemophilus influenzae (NTHI) bronchopneumonia used organisms bound to mouse fetal lung (MFL) cells as an inoculum. Pretreatment of the mice with 40 microL of 1% formalin 3 days before intranasal instillation of the bacteria was necessary to allow infection. The number of NTHI recovered from the lungs plus trachea on day 7 after instillation was >100 times the number originally inoculated. Later, however, the number of recovered bacteria diminished gradually, and by day 14 it was almost identical to the original inoculum size. Serum IgM also peaked on day 7 after infection, after which IgG increased while IgM decreased. Histologically, bronchoalveolar infiltration of neutrophils was observed on day 3 after inoculation and continued at least for the following 4 days. The present experiment demonstrates that MFL cells can protect bacteria that have invaded the cells from the opsonizing and killing activities of host humoral defense mechanisms.
补体介导的针对基因定义的流感嗜血杆菌荚膜转化体的血清活性。
影响因子：
3.8
作者：
Swift,AJ;Moxon,ER;Zwahlen,A;Winkelstein,JA
通讯作者：
Winkelstein,JA