Amniotic fluid proteins: maternal and fetal contributions.
Amniotic fluid proteins: maternal and fetal contributions.
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羊水蛋白质：母体和胎儿的贡献。
DOI：
10.1016/s0022-3476(74)80687-6
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
Gary Greenspan
中科院分区：
文献类型：
--
作者：
A. Johnson;A. Johnson;I. Umansky;C. Alper;Catherine Everett;Catherine Everett;Gary Greenspan;Gary Greenspan
通过灵敏的表型分析方法，未检测到胎儿对羊水类粘蛋白或 Gc 球蛋白的贡献。这些蛋白质的分子量相对较低，很容易被清除到尿液和其他体液中。由此看来，以及羊水与母体血清被动滤液的密切相似性，羊水中发现的成人型血浆蛋白几乎完全来自母体。 α1-胎儿蛋白可能主要通过胎儿肾脏排泄以外的途径进入羊水。大多数胎儿血浆蛋白的基因异常似乎不太可能通过羊水分析来检测。
No fetal contribution to amniotic fluid orosomucoid or Gc-globulin is detectable by sensitive methods of phenotyping. These proteins have relatively low molecular weights and are readily cleared into urine and other body fluids. It would appear from this and from the close similarity of amniotic fluid to a passive filtrate of maternal serum that the adult-type plasma proteins found in amniotic fluid are almost entirely of matermal origin. α1-Fetoprotein probably enters the amniotic fluid predominately by a route other than renal excretion by the fetus. It appears highly unlikely that genetically determined abnormalities of most fetal plasma proteins can be detected by analysis of amniotic fluid.