Effect of neonatal circumcision on pain response during subsequent routine vaccination
Effect of neonatal circumcision on pain response during subsequent routine vaccination
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DOI：
10.1016/s0140-6736(96)10316-0
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发表时间：
1997-03-01
期刊：
影响因子：
168.9
通讯作者：
Koren, G
中科院分区：
文献类型：
--
作者：
Taddio, A;Katz, J;Koren, G
背景初步研究表明，婴儿在新生儿期经历的疼痛可能会对未来的婴儿行为产生长期影响。本研究的目的是比较未割包皮的婴儿在4个月和6个月接种包皮环切术时是否改变了疼痛反应，以及用利多卡因-普里洛卡因乳膏(Emla)预处理包皮环切疼痛是否影响随后的疫苗接种反应。方法我们采用前瞻性队列设计对87名婴儿进行研究，这些婴儿分为三组-未割包皮的婴儿，以及在先前的临床试验中随机分配Emla或安慰剂的婴儿，以评估Emla乳膏作为新生儿包皮环切术疼痛预处理的效果，婴儿在初级保健医生诊所接种疫苗时被录像，一名研究助理在不知道包皮环切术或治疗状况的情况下对录像带进行评分，该助理接受过测量婴儿面部动作、哭泣持续时间和视觉模拟疼痛评分的培训。发现出生特征和接种疫苗时的婴儿特征，包括年龄和气质评分，在不同组之间没有显著差异。多变量方差分析显示显著的群体效应(p
Background Preliminary studies suggested that pain experienced by infants in the neonatal period may have long-lasting effects on future infant behaviour. The objectives of this study were to find out whether neonatal circumcision altered pain response at 4-month or 6-month vaccination compared with the response in uncircumcised infants, and whether pretreatment of circumcision pain with lidocaine-prilocaine cream (Emla) affects the subsequent vaccination response.Methods We used a prospective cohort design to study 87 infants, The infants formed three groups-uncircumcised infants, and infants who had been randomly assigned Emla or placebo in a previous clinical trial to assess the efficacy of Emla cream as pretreatment for pain in neonatal circumcision, Infants were Videotaped during vaccination done at the primary care physician's clinic, Videotapes were scored without knowledge of circumcision or treatment status by a research assistant who had been trained to measure infant facial action, cry duration, and visual analogue scale pain scores.Findings Birth characteristics and infant characteristics at the time of vaccination, including age and temperament scores, did not differ significantly among groups. Multivariate ANOVA revealed a significant group effect (p