COCCIDIOIDOMYCOSIS OF THE CENTRAL-NERVOUS-SYSTEM - NEUROPATHOLOGICAL AND VASCULOPATHIC MANIFESTATIONS AND CLINICAL CORRELATES
COCCIDIOIDOMYCOSIS OF THE CENTRAL-NERVOUS-SYSTEM - NEUROPATHOLOGICAL AND VASCULOPATHIC MANIFESTATIONS AND CLINICAL CORRELATES
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DOI：
10.1093/clinids/20.2.400
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发表时间：
1995-02-01
影响因子：
11.8
通讯作者：
VINTERS, HV
中科院分区：
文献类型：
--
作者：
MISCHEL, PS;VINTERS, HV
由于真菌球虫感染，这是地方性的美国西南部，目前正在发生流行病的比例。虽然它通常表现为亚临床感染或轻微的自限性肺部感染，但也可能发生播散性感染，特别是在免疫抑制的患者中。在播散性球孢子菌病患者中，中枢神经系统播散通常是导致显著发病率和死亡率的原因。神经病理改变的范围从脑膜炎到脑膜脑炎和脑脊炎，伴有广泛的实质破坏，有时是相关的闭塞性动脉内膜炎的结果。我们描述了一名艾滋病患者发展为中枢神经系统球孢子菌病，我们报告了在加州大学洛杉矶分校医学中心尸检的8名致命中枢神经系统球孢子菌病患者的临床病理分析结果。中枢神经系统球孢子菌病应被纳入神经系统症状患者的鉴别诊断，特别是当患者免疫抑制且生活在疾病流行地区时。
Infection due to the fungus Coccidioides immitis, which is endemic to the southwestern United States, is currently occurring in epidemic proportions. Although it usually presents as a subclinical infection or a mild, self-limited pulmonary infection, disseminated infection can occur, especially in immunosuppressed patients, In patients with disseminated coccidioidomycosis, CNS spread is commonly responsible for significant morbidity and mortality, The neurological presentations of C. immitis infection of the CNS are variable, The spectrum of neuropathological change ranges from meningitis to meningoencephalitis and meningomyelitis with extensive parenchymal destruction, sometimes as a result of an associated endarteritis obliterans. We describe a patient with AIDS who developed CNS coccidioidomycosis, and we report the findings of a clinicopathological analysis of eight patients with fatal CNS coccidioidomycosis who were autopsied at UCLA Medical Center. CNS coccidioidomycosis should be considered in the differential diagnosis of patients with neurological symptoms, especially when they are immunosuppressed and live in regions where the disease is endemic.