GROUP SEQUENTIAL DESIGNS USING A FAMILY OF TYPE-I ERROR-PROBABILITY SPENDING FUNCTIONS
GROUP SEQUENTIAL DESIGNS USING A FAMILY OF TYPE-I ERROR-PROBABILITY SPENDING FUNCTIONS
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DOI：
10.1002/sim.4780091207
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发表时间：
1990-12-01
影响因子：
2
通讯作者：
DECANI, JS
中科院分区：
文献类型：
--
作者：
HWANG, IK;SHIH, WJ;DECANI, JS
对临床试验中积累的数据执行计划内或计划外的中期分析是一种常见的做法。在这篇文章中，我们提出了一个通用的单参数族的第I类错误概率支出函数来构造信息时间中具有不等增量的定制组序列边界。这一族推广了Lan和DeMets1以及Kim和DeMets2的支出函数。
Performing planned or unplanned interim analyses on accumulating data in clinical trials is a frequent practice. In this paper, we propose a general one-parameter family of type I error probability spending functions to construct customized group sequential boundaries with unequal increments in information time. This proposed family generalizes the spending functions of Lan and DeMets1 and Kim and DeMets.2 We give an example to illustrate the use of this family.