Pressor sensitivities to vasopressin, angiotensin II, or methoxamine in diabetic rats.
Pressor sensitivities to vasopressin, angiotensin II, or methoxamine in diabetic rats.
复制标题
糖尿病大鼠对加压素、血管紧张素 II 或甲氧胺的升压敏感性。
DOI：
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发表时间：
1987
影响因子：
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通讯作者：
S. Gardiner
中科院分区：
文献类型：
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作者：
R. Hebden;T. Bennett;S. Gardiner
We investigated the pressor sensitivities to vasopressin, angiotensin II, and methoxamine of intact and ganglion-blocked rats that had been treated 21 days earlier with streptozotocin or saline. No differences in blood pressure or heart rate responses to vasopressin or angiotensin II were found between the intact groups when these peptides were administered intravenously in equimolar doses. After ganglion blockade a significant enhancement in pressor responsiveness to both vasopressin and angiotensin II was observed in the control groups, but in the streptozotocin-treated animals no enhancement in pressor sensitivity to vasopressin was found. Furthermore, although a significant augmentation of the responses to angiotensin II was observed, it was smaller than that seen in the ganglion-blocked control group. Neither group showed enhanced pressor responsiveness to methoxamine. These results indicate that the previously observed diminished contributions from endogenous vasopressin and the renin-angiotensin system to blood pressure recovery following ganglion blockade in streptozotocin-treated rats may have been due, at least in part, to diminished pressor responsiveness.
