Cervical dysplasia in Nigerian women infected with HIV
Cervical dysplasia in Nigerian women infected with HIV
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DOI：
10.1016/j.ijgo.2009.06.006
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发表时间：
2009-11-01
影响因子：
3.8
通讯作者：
Idoko, John A.
中科院分区：
文献类型：
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作者：
Agaba, Patricia A.;Thacher, Thomas D.;Idoko, John A.
目的：确定在尼日利亚乔斯大学教学医院接受治疗的艾滋病毒阳性妇女宫颈发育不良的患病率和危险因素。方法：对369例HIV阳性妇女进行宫颈细胞学检查，检测HIV-1 RNA病毒载量和CD 4计数。结果：在369名参与者中，107名（29.0%）妇女存在宫颈不典型增生。宫颈细胞学异常252例（68.3%）。在细胞学异常的患者中，145例（57.5%）为ASCUS，56例（22.2%）为LSIL，51例（20.2%）为HSIL。异型增生妇女的中位CD 4淋巴细胞计数低于非异型增生妇女（142 vs 170 cells/mm（3）; P = 0.04），而异型增生妇女的中位HIV RNA病毒载量高于非异型增生妇女（101781 vs 77479 copies/mL：P = 0.002）。CD 4 + T细胞亚群（
Objective: To determine the prevalence of and risk factors for cervical dysplasia in HIV-positive women receiving care at the Jos University Teaching Hospital in Nigeria. Methods: A total of 369 HIV-positive women had cervical cytology performed; HIV-1 RNA viral load and CD4 counts were measured. Results: Of 369 participants, cervical dysplasia was present in 107 (29.0%) women. However, cervical cytology was abnormal in 252 (68.3%). Among those with abnormal cytology, 145 (57.5%) women had ASCUS, 56 (22.2%) had LSIL, and 51 (20.2%) had HSIL. Median CD4 lymphocyte count was lower in women with dysplasia compared with those without (142 vs 170 cells/mm(3); P = 0.04), while median HIV RNA viral load was higher in women with dysplasia (101781 vs 77 479 copies/mL: P = 0.002). Low CD4 count (