Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages.
Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages.
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DOI：
10.1084/jem.172.6.1853
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发表时间：
1990-12-01
期刊：
影响因子：
--
通讯作者：
Silverstein SC
中科院分区：
文献类型：
--
作者：
Greenberg S;Burridge K;Silverstein SC
我们研究了talin在接受Fc受体介导吞噬的J774细胞和小鼠腹膜巨噬细胞中的分布。在吞噬的早期阶段，talin积聚在靠近形成吞噬体的细胞皮层细胞质中，并延伸到环绕颗粒的伪足。Talin与f -肌动蛋白在这些位点共定位。颗粒摄取完成后，f -肌动蛋白和talin不再集中在吞噬体附近。因此，在Fc受体介导的吞噬过程中，talin和F- actin的细胞质位置发生了动态和协调的变化。
We have studied the distribution of talin in J774 cells and mouse peritoneal macrophages undergoing Fc receptor-mediated phagocytosis. At early stages of phagocytosis, talin accumulates in the cells' cortical cytoplasm adjacent to the forming phagosome and extends into pseudopods that are encircling the particle. Talin colocalizes with F-actin at these sites. After particle ingestion is completed, F-actin and talin are no longer concentrated adjacent to phagosomes. Thus, talin and F- actin undergo dynamic and coordinate changes in their cytoplasmic location during Fc receptor-mediated phagocytosis.