Pyridoxine deficiency influences the behavior of the glucocorticoid . receptor complex.
Pyridoxine deficiency influences the behavior of the glucocorticoid . receptor complex.
复制标题
吡哆醇缺乏会影响糖皮质激素的作用。
DOI：
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发表时间：
1980
影响因子：
4.8
通讯作者：
G. Litwack
中科院分区：
文献类型：
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作者：
D. Disorbo;D. Phelps;V. S. Ohl;G. Litwack
吡哆醇缺乏导致可激活的肝糖皮质激素*受体复合物数量增加，并加速复合物向体外核的易位速率。在25℃热激活15分钟后，pyrido啶缺乏的细胞质中74%的甾体受体复合物与细胞核结合，而对照组为29%。par-tially恢复
Pyridoxine deficiency results in an increased number of activatable hepatic glucocorticoid *receptor com- plexes and an accelerated rate of translocation of the complexes to nuclei in vitro. After 15 min of heat acti- vation at 25”C, 74% of the steroidoreceptor complexes from pyridoxine-deficient cytosol were bound to nuclei compared to 29% from controls. par-tially restored