The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables.
The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables.
复制标题
结直肠癌中的TP53肿瘤抑制基因。 ii。与DNA倍虫模式和临床病理变量的关系。
DOI：
10.1038/bjc.1993.15
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发表时间：
1993-01
影响因子：
8.8
通讯作者：
Rognum, T O
中科院分区：
文献类型：
--
作者：
Meling, G I;Lothe, R A;Borresen, A L;Graue, C;Hauge, S;Clausen, O P;Rognum, T O
在结直肠癌中，染色体臂17 p上TP53基因的杂合丢失与DNA非整倍体密切相关（P <0.0001）。这种相关性仅见于17 p和17 q缺失的肿瘤（P <0.001），但仅见于17 p缺失的肿瘤。DNA指数>或= 1.1和<1.3的DNA近二倍体（ND）癌和DNA非整倍体（AN）肿瘤具有相似的TP53基因丢失频率（分别为49%和42%），而DNA指数>或= 1.3的AN肿瘤具有显著更高的TP53基因丢失频率（85%）。（P <0.0001和P <0.0001）。TP 53基因缺失与组织学分级显著相关（P <0.01），TP 53基因缺失与细胞浸润程度相关（P <0.05），TP 53基因缺失分别在中分化癌和重度细胞浸润癌中最常见。TP53基因缺失的肿瘤比例在大肠远端显著增加（P <0.0001）。这些结果表明，不同的遗传机制可能参与了结肠癌和直肠癌，并在两个子集的DNA非整倍体癌。此外，这些数据可能表明TP53基因在非整倍体化过程中的作用，可能是整个染色体丢失的“靶标”。
Heterozygous loss of the TP53 gene on chromosome arm 17p in colorectal carcinomas was strongly associated with DNA aneuploidy (P < 0.0001). This association was seen only in tumours with loss on both 17p and 17q (P < 0.001), but not for loss on 17p only. DNA near diploid (ND) carcinomas and DNA aneuploid (AN) tumours with DNA index > or = 1.1 and < 1.3 had similar frequencies of TP53 gene loss (49% and 42%, respectively), whereas AN tumours with DNA index > or = 1.3 had a significantly higher frequency of TP53 gene loss (85%) (P < 0.0001 and P < 0.0001, respectively). There was a significant association between loss of the TP53 gene and histological grade (P < 0.01), and there tended to be an association between loss of the TP53 gene and degree of cellular atypia (P < 0.05), with TP53 gene loss being most frequent in moderately differentiated carcinomas, and in carcinomas with severe cellular atypia, respectively. The proportion of tumours with loss of the TP53 gene increased significantly towards the distal part of the large bowel (P < 0.0001). These results indicate that different genetic mechanisms may be involved in the carcinogenesis in colon and rectum carcinomas, and in the two subsets of DNA aneuploid carcinomas. Furthermore, the data may suggest a role for the TP53 gene in the aneuploidisation process, possibly as a 'target' for a whole chromosome loss.