Chorionic villus sampling and hemangiomas.
Chorionic villus sampling and hemangiomas.
复制标题
绒毛膜绒毛取样和血管瘤。
DOI：
10.1097/scs.0b013e318193d61a
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Holmes,LewisB
中科院分区：
文献类型：
--
作者：
Holmes,LewisB
绒毛取样(CVS)是一种应用广泛、安全的产前诊断方法。在20世纪90年代，几个医学中心提出了担忧，认为暴露的胎儿发生肢体缺陷、血管瘤和其他血管破裂缺陷的风险增加。当手术在怀孕早期进行时，例如怀孕8周或9周时，风险更大。胎儿损伤的可能机制包括失血、低灌流、缺氧、内皮细胞损伤、出血和组织丢失。这种影响在有末端动脉的组织中最为常见，如手指、舌头、脑干和肠道。合并血管瘤为婴幼儿血管瘤。它们更常见于头部、颈部和胸部，在暴露于CVS的婴儿中更常见。这些血管瘤发生的一个假设机制是血管母细胞或内皮细胞从胎盘到胎儿皮肤的栓塞。一个需要回答的问题是，暴露于CVS的儿童中的婴儿血管瘤在免疫组织学特征上是否与怀孕期间未暴露于CVS的儿童中的类似血管瘤不同。
Chorionic villus sampling (CVS) is a widely used and safe method of prenatal diagnosis. In the 1990s, concerns were raised at several medical centers that there was an increased risk to the exposed fetus for the occurrence of limb deficiencies, hemangiomas, and other vascular disruption defects. The risk was greater when the procedure was performed earlier in pregnancy, such as 8 or 9 weeks of gestation. The postulated mechanisms for the fetal injury included blood loss, hypoperfusion, hypoxia, endothelial cell damage, hemorrhage, and tissue loss. The effect was most common in tissues with end arteries, such as digits, tongue, brain stem, and intestine. The associated hemangiomas were infantile hemangiomas. They were more common on the head, neck, and thorax and more often multiple in infants exposed to CVS. One postulated mechanism for the occurrence of these hemangiomas is embolization of angioblasts or endothelial cells from the placenta to the fetal skin. A question to be answered is whether the infantile hemangiomas in children exposed to CVS differ in immunohistologic characteristics from similar hemangiomas in children not exposed to CVS during pregnancy.