ELECTRICAL-STIMULATION OF THE HUMAN BRAIN IN EPILEPSY
ELECTRICAL-STIMULATION OF THE HUMAN BRAIN IN EPILEPSY
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DOI：
10.1111/j.1528-1157.1990.tb06099.x
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发表时间：
1990-09-01
期刊：
影响因子：
5.6
通讯作者：
SAINTHILAIRE, JM
中科院分区：
文献类型：
--
作者：
BERNIER, GP;RICHER, F;SAINTHILAIRE, JM
对126例难治性癫痫患者颅内记录的自发性癫痫发作和电诱发先兆或癫痫发作的致痫区域进行了一致性研究。作为术前检查程序的一部分，在患者体内长期植入4 - 11个多触点深度电极。癫痫区域的定位是从三次自发性癫痫发作的记录和刺激数据（包括自我报告的先兆、癫痫发作和在所有皮质接触对的增量刺激序列期间记录的颅内EEG后放电）中获得的。在63%的患者中获得了对刺激的阳性反应。自发性和诱发性先兆或癫痫发作之间的一致性在单单侧病灶中>90%，在多病灶中较少。刺激数据可靠地预测了单侧和双侧颞部病灶的切除面积，但在其他位置则不然。后放电阈值不是自发性癫痫灶的可靠预测因子。所用颅内刺激程序似乎提供了与自发性癫痫发作相关的有用的确认性和补充性定位信息。
The concordance between the epileptogenic area as determined by intracranially recorded spontaneous seizure onset and that determined by electrically induced auras or seizures in 126 patients with medically intractable epilepsy was studied. Four to 11 multicontact depth electrodes were chronically implanted in patients as part of a preoperative investigation procedure. Localization of the epileptic area was obtained from the recording of three spontaneous seizures and from stimulation data including self-reported auras, seizures, and intracranial EEG afterdischarges recorded during an incremental stimulation sequence at all cortical pairs of contacts. Positive responses to stimulation were obtained in 63% of patients. Concordance between spontaneous and induced auras or seizures was >90% with single unilateral foci and less with multiple foci. Stimulation data reliably predicted the resection area in unilateral and bilateral temporal foci but not in other locations. Afterdischarge thresholds were not reliable predictors of the spontaneous seizure focus. The intracranial stimulation procedure used appears to provide useful confirmatory and complementary localizing information in relation to that obtained from spontaneous seizures.