Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview.
Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview.
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DOI：
10.1186/1479-5876-9-171
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发表时间：
2011-10-10
影响因子：
7.4
通讯作者：
Sperlongano P
中科院分区：
文献类型：
--
作者：
Marra M;Sordelli IM;Lombardi A;Lamberti M;Tarantino L;Giudice A;Stiuso P;Abbruzzese A;Sperlongano R;Accardo M;Agresti M;Caraglia M;Sperlongano P
肝细胞癌（HCC）是一种复杂的异质性肿瘤，存在多种遗传变异.肝癌的发生与细胞增殖和死亡的调控有关。肝癌的主要病因是B肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染。持续氧化应激是由环境因素或细胞线粒体功能障碍引起的活性氧（ROS）产生的结果，最近被认为与肝癌的发生有关。另一方面，HCC的一个独特的病理标志是氧化还原酶的急剧下调，这些酶构成了以过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶为代表的最重要的自由基清除剂系统。多激酶抑制剂索拉非尼代表了最有前途的靶向药物，已经在晚期HCC患者中进行了广泛的研究，直至III期临床试验。与其他靶向药物联合使用可增强索拉非尼单药的临床获益。事实上，一项II期多中心研究已经证明索拉非尼和奥曲肽LAR联合治疗（So.LAR方案）在晚期HCC患者中具有活性和良好的耐受性。检测对索拉非尼等抗癌药物应答的分子预测因子和鉴定对抗癌药物的耐药机制可能代表改善HCC治疗的方向。
Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple genetic aberrations. Several molecular pathways involved in the regulation of proliferation and cell death are implicated in the hepatocarcinogenesis. The major etiological factors for HCC are both hepatitis B virus (HBV) and hepatitis C virus infection (HCV). Continuous oxidative stress, which results from the generation of reactive oxygen species (ROS) by environmental factors or cellular mitochondrial dysfunction, has recently been associated with hepatocarcinogenesis. On the other hand, a distinctive pathological hallmark of HCC is a dramatic down-regulation of oxido-reductive enzymes that constitute the most important free radical scavenger systems represented by catalase, superoxide dismutase and glutathione peroxidase. The multikinase inhibitor sorafenib represents the most promising target agent that has undergone extensive investigation up to phase III clinical trials in patients with advanced HCC. The combination with other target-based agents could potentiate the clinical benefits obtained by sorafenib alone. In fact, a phase II multicenter study has demonstrated that the combination between sorafenib and octreotide LAR (So.LAR protocol) was active and well tolerated in advanced HCC patients. The detection of molecular factors predictive of response to anti-cancer agents such as sorafenib and the identification of mechanisms of resistance to anti-cancer agents may probably represent the direction to improve the treatment of HCC.
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影响因子：
5
作者：
Andres Rubiolo, Juan;Mithieux, Gilles;Victor Vega, Felix
通讯作者：
Victor Vega, Felix
DOI：
10.1007/bf02593907
发表时间：
1994-05-01
期刊：
INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH
影响因子：
--
作者：
CASARIL, M;CORSO, F;CORROCHER, R
通讯作者：
CORROCHER, R
影响因子：
6.1
作者：
Addeo, Raffaele;Caraglia, Michele;Del Prete, Salvatore
通讯作者：
Del Prete, Salvatore
影响因子：
9
作者：
通讯作者：
--
影响因子：
45.3
作者：
Abou-Alfa, Ghassan K.;Schwartz, Lawrence;Saltz, Leonard B.
通讯作者：
Saltz, Leonard B.