Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients
Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients
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DOI：
10.1177/0961203316635286
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发表时间：
2016-10-01
期刊：
影响因子：
2.6
通讯作者：
Acosta-Reyes, J.
中科院分区：
文献类型：
--
作者：
Munoz-Grajales, C.;Gonzalez, L. A.;Acosta-Reyes, J.
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Objective The objective of this paper is to compare disease activity and clinical features at diagnosis in male and female patients with systemic lupus erythematosus (SLE).Methods This was a cross-sectional study in which every male patient (n=40) was matched with three female patients of the same age (5 years) and racial/ethnic group; disease activity as per the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and disease manifestations at the time of diagnosis were compared.Results Alopecia and anti-Ro antibodies were more frequent in female patients. No statistically significant difference in any other disease characteristics was found. However, male gender was associated with a risk of severe disease activity at the time of diagnosis (as determined by SLEDAI 12 score) independent of age, racial/ethnic group, anti-Ro positivity or time to criteria accrual (OR: 3.11 95% CI, 1.09-8.92; p=0.035).Conclusion In newly diagnosed SLE patients, male gender is associated with higher disease activity despite the fact that male and female patients seem to experience similar overall disease manifestations.