Palladium-Catalyzed Cascade Reactions of -Halo-N-Tosylhydrazones, Indoles, and Aryl Iodides
Palladium-Catalyzed Cascade Reactions of -Halo-N-Tosylhydrazones, Indoles, and Aryl Iodides
复制标题
钯催化的卤代-N-甲苯磺酰腙、吲哚和芳基碘化物的级联反应
DOI：
10.1002/ajoc.201600137
复制
发表时间：
2016
影响因子：
2.7
通讯作者：
Wang Jianbo
中科院分区：
文献类型：
--
作者：
Wu Guojiao;Deng Yifan;Luo Haiqing;Li Tianjiao;Zhang Yan;Wang Jianbo
在钯催化的三组分反应中，α - Halo - N - tosylhydra腙作为多种碳-碳键形成的试剂进行了探索。设计了一种转化策略，通过使用亲核试剂与α -晕- N -甲苯腙原位生成的偶氮烯烃中间体反应生成重氮中间体，该中间体进一步与芳基碘化物进行钯催化的C−C键形成反应。
α‐Halo‐N‐tosylhydrazones are explored as reagents for the multiple carbon–carbon bond formations in palladium‐catalyzed three‐component reactions. A strategy has been designed for this transformation by using a nucleophile to react with the azoalkene intermediate formed in situ from the α‐halo‐N‐tosylhydrazone to generate the diazo intermediate, which is further subjected to palladium‐catalyzed C−C bond forming reactions with aryl iodides.