Host-virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptor
Host-virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptor
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DOI：
10.1016/j.cimid.2008.10.003
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发表时间：
2010-05-01
影响因子：
2
通讯作者：
Maruyama, Tadashi
中科院分区：
文献类型：
--
作者：
Ohishi, Kazue;Ando, Akiko;Maruyama, Tadashi
信号淋巴细胞激活分子（SLAM）被认为是高宿主特异性麻疹病毒的主要细胞受体，这种病毒在哺乳动物中引起毁灭性和高度传染性疾病。我们确定了5种海洋哺乳动物（包括2种鲸目动物、2种鳍足动物和1种海龙类动物）的SLAM cDNA序列，并建立了三维模型来了解受体与病毒的相互作用。在SLAMS的免疫球蛋白样V结构域的21个氨基酸残基被证明与病毒蛋白结合。值得注意的是，鳍足动物和狗的序列高度同源，这与之前证明犬瘟热病毒导致海豹大量死亡的事实是一致的。在这21个残基中，有8个（63、66、68、72、84、119、121和130）为对某一种麻疹病毒易感的动物群体所共有。这组残基似乎决定了宿主病毒的特异性，并可能对麻疹病毒的风险估计有用。(C) 2008 Elsevier Ltd版权所有。
Signaling lymphocyte activation molecule (SLAM) is thought to be a major cellular receptor for high-host specificity morbilliviruses, which cause devastating and highly infectious diseases in mammals. We determined the sequences of SLAM cDNA from five species of marine mammal, including two cetaceans, two pinnipeds and one sirenian, and generated three-dimensional models to understand the receptor-virus interaction. Twenty-one amino acid residues in the immunoglobulin-like V domains of the SLAMS were shown to bind the viral protein. Notably, the sequences from pinnipeds and dogs were highly homologous, which is consistent with the fact that canine distemper virus was previously shown to cause a mass die-off of seals. Among these twenty-one residues, eight (63, 66, 68, 72, 84, 119, 121 and 130) were shared by animal groups susceptible to a particular morbillivirus species. This set of residues appears to determine host virus specificity and may be useful for risk estimation for morbilliviruses. (C) 2008 Elsevier Ltd. All rights reserved.