Central reorganization of sensory pathways following peripheral nerve regeneration in fetal monkeys
Central reorganization of sensory pathways following peripheral nerve regeneration in fetal monkeys
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DOI：
10.1038/381069a0
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发表时间：
1996-05-02
期刊：
影响因子：
64.8
通讯作者：
Kaas, JH
中科院分区：
文献类型：
--
作者：
Florence, SL;Jain, N;Kaas, JH
成人感觉神经的切断导致感觉知觉的严重异常，即使切断的神经被手术修复以促进准确的神经再生，与此形成鲜明对比的是，儿童神经切断和手术修复后的知觉错误较少（1-3），儿童这种上级恢复的基础尚不清楚。在此，Rye表明，在未成熟的猕猴中，在正中神经切除和手术修复后，手的正中神经中几乎没有或没有拓扑结构顺序。然而，值得注意的是，在相同的动物中，在初级躯体感觉皮层（3b区）中重新神经支配的手的表示是相当有序的，这表明发育中的大脑中存在可以创建皮层拓扑结构的机制，尽管感觉输入紊乱据推测，儿童外周神经切断后知觉能力的上级恢复取决于中枢感觉地图中躯体适应性的恢复。
TRANSECTION Of a sensory nerve in adults results in profound abnormalities in sensory perception, even if the severed nerve is surgically repaired to facilitate accurate nerve regeneration, In marked contrast, fewer perceptual errors follow nerve transection and surgical repair in children(1-3), The basis for this superior recovery in children was unknown. Here rye show that there is little or no topographic order in the median nerve to the hand after median nerve section and surgical repair in immature macaque monkeys, Remarkably, however, in the same animals the representation of the reinnervated hand in primary somatosensory cortex (area 3b) is quite orderly, This indicates that there are mechanisms in the developing brain that can create cortical topography, despite disordered sensory inputs. Presumably the superior recovery of perceptual abilities after peripheral nerve transection in children depends on this restoration of somatotopy in the central sensory maps.