Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study.
Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study.
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DOI：
10.1136/bmjopen-2020-040569
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发表时间：
2020-09-29
期刊：
影响因子：
2.9
通讯作者：
COPE Study Collaborators
中科院分区：
文献类型：
--
作者：
Price A;Barlow-Pay F;Duffy S;Pearce L;Vilches-Moraga A;Moug S;Quinn T;Stechman M;Braude P;Mitchell E;Myint PK;Verduri A;McCarthy K;Carter B;Hewitt J;COPE Study Collaborators
本方案描述了一项观察性研究，旨在评估欧洲多中心环境中确诊为COVID-19的患者的虚弱和/或多发性硬化是否与短期和中期结局相关。在3个月的时间内，我们的目标是在10家医院招募至少500名患者，收集基线数据，包括：患者人口统计学;合并症的存在;入院时的相关血液检查; ACE抑制剂/血管紧张素受体阻滞剂/非甾体抗炎药/免疫抑制剂的处方;吸烟状况;临床虚弱评分（CFS）;住院时间;死亡率和再入院。所有接受住院治疗的18岁以上确诊为COVID-19的患者都有资格入选。计划在6个月和12个月时进行长期随访。这将评估虚弱，生活质量和医疗并发症。我们的主要分析将是CFS的短期和长期死亡率，并根据年龄（18-64岁，65-80岁和>80岁）和性别进行调整。我们将通过纳入使用似然比检验确定具有统计学意义的其他临床介质，对主要结局进行次要分析。所有分析将以粗略和校正的HR和OR以及相关的95% CI和p值表示。本研究已由以下机构注册、审查和批准：健康研究机构（20/HRA 1898）;意大利摩德纳医院伦理委员会（369/2020/OSS/AOUMO）;威尔士健康与护理研究中心;苏格兰NHS研究中心协调中心。所有参与单位均获得当地研发部门的批准，并符合相关国家组织的指导。数据将作为整个队列报告。该项目将提交给国家或国际外科和老年医学会议。将在项目结束后编制手册。
This protocol describes an observational study which set out to assess whether frailty and/or multimorbidity correlates with short-term and medium-term outcomes in patients diagnosed with COVID-19 in a European, multicentre setting. Over a 3-month period we aim to recruit a minimum of 500 patients across 10 hospital sites, collecting baseline data including: patient demographics; presence of comorbidities; relevant blood tests on admission; prescription of ACE inhibitors/angiotensin receptor blockers/non-steroidal anti-inflammatory drugs/immunosuppressants; smoking status; Clinical Frailty Score (CFS); length of hospital stay; mortality and readmission. All patients receiving inpatient hospital care >18 years who receive a diagnosis of COVID-19 are eligible for inclusion. Long-term follow-up at 6 and 12 months is planned. This will assess frailty, quality of life and medical complications. Our primary analysis will be short-term and long-term mortality by CFS, adjusted for age (18–64, 65–80 and >80) and gender. We will carry out a secondary analysis of the primary outcome by including additional clinical mediators which are determined statistically important using a likelihood ratio test. All analyses will be presented as crude and adjusted HR and OR with associated 95% CIs and p values. This study has been registered, reviewed and approved by the following: Health Research Authority (20/HRA1898); Ethics Committee of Hospital Policlinico Modena, Italy (369/2020/OSS/AOUMO); Health and Care Research Permissions Service, Wales; and NHS Research Scotland Permissions Co-ordinating Centre, Scotland. All participating units obtained approval from their local Research and Development department consistent with the guidance from their relevant national organisation. Data will be reported as a whole cohort. This project will be submitted for presentation at a national or international surgical and geriatric conference. Manuscript(s) will be prepared following the close of the project.
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DOI：
10.1186/cc9297
发表时间：
2011
期刊：
Critical care (London, England)
影响因子：
--
作者：
McDermid RC;Stelfox HT;Bagshaw SM
通讯作者：
Bagshaw SM
影响因子：
2.3
作者：
Hewitt, Jonathan;Owen, Stephanie;Moug, Susan J.
通讯作者：
Moug, Susan J.
影响因子：
6.7
作者：
Hewitt, J.;Carter, B.;Myint, P. K.
通讯作者：
Myint, P. K.
影响因子：
3
作者：
Wagner, Brooklyn;Royal, Kenneth;Pairis-Garcia, Monique
通讯作者：
Pairis-Garcia, Monique
老年患者的紧急剖腹手术：可预测12个月死亡率 - 萨尔福德 - pops-gs的因素。观察性研究。
影响因子：
4
作者：
Vilches-Moraga A;Rowley M;Fox J;Khan H;Paracha A;Price A;Pearce L
通讯作者：
Pearce L