(n‐6)‐Fatty acids in plasma lipids of children with atopic bronchial asthma
(n‐6)‐Fatty acids in plasma lipids of children with atopic bronchial asthma
复制标题
特应性支气管哮喘儿童血脂中的 (n-6)-脂肪酸
DOI：
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发表时间：
1995
影响因子：
4.4
通讯作者：
Paul
中科院分区：
文献类型：
--
作者：
Leichsenring M. Kochsiek;U.;Paul
It has been suggested that atopy is associated with an impairment in the δ6‐desaturation of (n‐6)‐polyunsaturated fatty acids and subsequently low levels of eicosanoid precursors. To evaluate this hypothesis we analyzed the fatty acid composition of plasma phospholipids and plasma cholesterolest‐ers in a well‐defined group of children with atopic bronchial asthma (n = 17) and age‐matched healthy controls (n = 10). Atopic children showed significantly higher levels of linoleic acid and lower proportions of arachidonic acid in plasma lipids. No differences were observed with respect to γ‐lino‐lenic acid (GLA) and dihomo‐γ‐linolenic acid (DHLA). It is concluded that there is no biochemical evidence for a δ6‐desaturation defect in atopic children and therefore no justification for the supplementation of GLA and DHLA; e.g. by the use of evening primrose oil preparations.
影响因子：
13.6
作者：
R. Holman;S. Johnson
通讯作者：
R. Holman;S. Johnson