COMPASS 31: A Refined and Abbreviated Composite Autonomic Symptom Score
COMPASS 31: A Refined and Abbreviated Composite Autonomic Symptom Score
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DOI：
10.1016/j.mayocp.2012.10.013
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发表时间：
2012-12-01
影响因子：
8.9
通讯作者：
Singer, Wolfgang
中科院分区：
文献类型：
--
作者：
Sletten, David M.;Suarez, Guillermo A.;Singer, Wolfgang
目的：开发一种简洁且统计可靠的工具来评估自主症状，该工具基于已建立的169项自主症状谱（ASP）及其经过验证的84题评分工具——复合自主症状评分（COMPASS），提供自主症状严重程度的临床相关评分。患者和方法：我们基于1995年3月1日至2010年3月31日在梅奥诊所自主神经障碍中心招募的405名健康对照者的ASP，使用Cronbach alpha系数评估COMPASS的内部一致性。然后，我们采用简化的评分算法，利用正交旋转和特征值计算的探索性因子分析来提取内部一致域并降低维数。分析后由专家进行修订，以消除冗余内容，保留临床重要问题和对新仪器的最终评估。结果：新的简化评分算法单独在各领域的Cronbach alpha值较高。因子分析显示了7个领域，总共保留了54个问题。专家修订导致问题和领域进一步减少，在6个领域（COMPASS 31）中剩余的31个问题。与COMPASS相比，内部一致性的测量有了很大的改进。根据适当的加权，该仪器提供从0到100的自主神经症状评分。结论：COMPASS 31是一种精细的、内部一致的、明显缩短的自主神经症状定量测量方法。它以原有的ASP和COMPASS为基础，采用了一种大大简化的评分算法，适合广泛应用于自主学习的研究和实践。(C) 2012年梅奥医学教育与研究基金会广场梅奥诊所项目；87 (12): 1196 - 1201
Objective: To develop a concise and statistically robust instrument to assess autonomic symptoms that provides clinically relevant scores of autonomic symptom severity based on the well-established 169-item Autonomic Symptom Profile (ASP) and its validated 84-question scoring instrument, the Composite Autonomic Symptom Score (COMPASS).Patients and Methods: We assessed the internal consistency of COMPASS using Cronbach alpha coefficients based on the ASP of 405 healthy control subjects recruited and seen in the Mayo Clinic Autonomic Disorders Center between March 1, 1995, and March 31, 2010. Applying a simplified scoring algorithm, we then used exploratory factor analysis with orthogonal rotation and eigenvalue calculations to extract internally consistent domains and to reduce dimensionality. This analysis was followed by expert revisions to eliminate redundant content and to retain clinically important questions and final assessment of the new instrument.Results: The new simplified scoring algorithm alone resulted in higher Cronbach alpha values in all domains. Factor analysis revealed 7 domains with a total of 54 questions retained. Expert revisions resulted in further reduction of questions and domains with a remaining total of 31 questions in 6 domains (COMPASS 31). Measures of internal consistency were much improved compared to those for COMPASS. Following appropriate weighting, this instrument provides an autonomic symptom score from 0 to 100.Conclusion: COMPASS 31 is a refined, internally consistent, and markedly abbreviated quantitative measure of autonomic symptoms. It is based on the original ASP and COMPASS, applies a much simplified scoring algorithm, and is suitable for widespread use in autonomic research and practice. (C) 2012 Mayo Foundation for Medical Education and Research square Mayo Clin Proc. 2012; 87(12): 1196-1201