The diet-microbiota axis: a key regulator of intestinal permeability in human health and disease.
The diet-microbiota axis: a key regulator of intestinal permeability in human health and disease.
复制标题
饮食-微生物轴：人类健康和疾病中肠道通透性的关键调节因子。
DOI：
10.1080/21688370.2022.2077069
复制
发表时间：
2023
期刊：
影响因子：
3.1
通讯作者：
Singh,AmarB
中科院分区：
文献类型：
--
作者：
LamaTamang,Raju;Juritsch,AnthonyF;Ahmad,Rizwan;Salomon,JeffreyD;Dhawan,Punita;Ramer-Tait,AmandaE;Singh,AmarB
肠道屏障对营养物质和代谢物具有选择性的渗透性，同时排除有害刺激。最近的科学进步证实了肠道微生物区系在人类健康结果中的因果作用，这引起了人们对肠道通透性的重新兴趣。考虑到肠道屏障在抵御外来抗原方面的既定作用，越来越多的证据表明，肠道通透性与微生物群在调节人类健康方面存在因果联系。然而，对控制肠道屏障功能的动态宿主-微生物区系相互作用的了解仍然很少。此外，益生菌和益生菌等微生物群靶向治疗同时促进肠道屏障功能和宿主健康的系统水平机制仍然是一个积极的研究领域。本文综述了近年来有关肠道通透性与人体健康的关系及其与肠道微生物区系整合的研究进展。我们进一步总结了益生菌/益生菌影响肠道微生物区系和肠道屏障功能的机制。
The intestinal barrier orchestrates selective permeability to nutrients and metabolites while excluding noxious stimuli. Recent scientific advances establishing a causal role for the gut microbiota in human health outcomes have generated a resurgent interest toward intestinal permeability. Considering the well-established role of the gut barrier in protection against foreign antigens, there is mounting evidence for a causal link between gut permeability and the microbiome in regulating human health. However, an understanding of the dynamic host–microbiota interactions that govern intestinal barrier functions remains poorly defined. Furthermore, the system-level mechanisms by which microbiome-targeted therapies, such as probiotics and prebiotics, simultaneously promote intestinal barrier function and host health remain an area of active investigation. This review summarizes the recent advances in understanding the dynamics of intestinal permeability in human health and its integration with gut microbiota. We further summarize mechanisms by which probiotics/prebiotics influence the gut microbiota and intestinal barrier functions.