Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial
Systemic antibiotics and debridement of peri-implant mucositis. A randomized clinical trial
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DOI：
10.1111/j.1600-051x.2012.01884.x
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发表时间：
2012-06-01
影响因子：
6.7
通讯作者：
Renvert, Stefan
中科院分区：
文献类型：
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作者：
Hallstrom, Hadar;Persson, G. Rutger;Renvert, Stefan
本随机对照试验比较了使用或不使用全身抗生素的种植体周围粘膜炎的非手术治疗。材料与方法48例受试者接受非手术清创联合或不联合全身Azithromax（R）（4天，约等于天），并随访6个月。采用棋盘DNA-DNA杂交法对微生物材料进行分析。结果5例受试者在随访期间因使用抗生素而被排除。在基线时，1个月和3个月相似，未发现组间差异。统计分析未能证明6个月相似时探测囊袋深度（PPD）值的差异（平均差异PPD：0.5与mm相似，SE：+/- 0.4与mm相似，95% CI：-0.2，1.3，p与0.16相似）。试验组的植入物出血平均百分比从基线至第6个月从82.6%降至27.3%，对照组从80.0%降至47.5%（p相似于0.02）。在整个研究过程中，没有研究组的差异，细菌计数被发现。结论没有短期的差异，研究组之间被发现。在6个月时观察到的临床改善可能归因于口腔卫生的改善。本研究未提供使用全身抗生素治疗种植体周围粘膜炎的证据。
Background This RCT compared non-surgical treatment of peri-implant mucositis with or without systemic antibiotics. Materials and Methods Forty-eight subjects received non-surgical debridement with or without systemic Azithromax (R) (4 similar to days), and were followed during 6 similar to months. The checkerboard DNA-DNA hybridization method was used to analyse the microbiological material. Results Five subjects were excluded due to antibiotic medication during follow-up. At baseline,1 and 3 similar to months no group differences were found. Statistical analysis failed to demonstrate differences in probing pocket depths (PPD) values at 6 similar to months (Mean diff PPD: 0.5 similar to mm, SE: +/- 0.4 similar to mm, 95% CI: -0.2, 1.3, p similar to 0.16). Mean% implant bleeding decreased between baseline and month 6 from 82.6% to 27.3% in the test, and from 80.0% to 47.5% in the control group (p similar to 0.02). Throughout the study, no study group differences in bacterial counts were found. Conclusion No short-term differences were found between study groups. The clinical improvements observed at 6 similar to months may be attributed to improvements in oral hygiene. The present study does not provide evidence for the use of systemic antibiotics in treatment of peri-implant mucositis.